ReviewFrontiers in immunology2018
Emerging Developments in Microbiome and Microglia Research: Implications for Neurodevelopmental Disorders.
Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Germ-free piglets display variable neuroinflammatory-like perturbations in prefrontal cortical microglia.bioRxiv : the preprint server for biology · 2026Article
- Gene×environment interactions in autism spectrum disorders.Current topics in developmental biology · 2023Review
- Advances in the study of the effects of gut microflora on microglia in Alzheimer's disease.Frontiers in molecular neuroscience · 2023Review
- Searching for host immune-microbiome mechanisms in obsessive-compulsive disorder: A narrative literature review and future directions.Neuroscience and biobehavioral reviews · 2021Review
- Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice.Scientific reports · 2021Article
- A Developmental Analysis of Juxtavascular Microglia Dynamics and Interactions with the Vasculature.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Role of Microglia in Neurodevelopmental Disorders and their Therapeutics.Current topics in medicinal chemistry · 2020Review
- What Does Immunology Have to Do With Normal Brain Development and the Pathophysiology Underlying Tourette Syndrome and Related Neuropsychiatric Disorders?Frontiers in neurology · 2020Review
- The role of the gut microbiome in mediating neurotoxic outcomes to PCB exposure.Neurotoxicology · 2019Review
- Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice.Scientific reports · 2019Article
- Regulatory Roles of Sortilin and SorLA in Immune-Related Processes.Frontiers in pharmacology · 2018Review
- Bacteroides-dominant gut microbiome of late infancy is associated with enhanced neurodevelopment.Gut microbesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
From immunology to neuroscience, interactions between the microbiome and host are increasingly appreciated as potent drivers of health and disease. Epidemiological studies previously identified compelling correlations between perinatal microbiome insults and neurobehavioral outcomes, the mechanistic details of which are just beginning to take shape thanks to germ-free and antibiotics-based animal models. This review summarizes parallel developments from clinical and preclinical research that suggest neuroactive roles for gut bacteria and their metabolites. We also examine the nascent field of microbiome-microglia crosstalk research, which includes pharmacological and genetic strategies to inform functional capabilities of microglia in response to microbial programming. Finally, we address an emerging hypothesis behind neurodevelopmental disorders, which implicates microbiome dysbiosis in the atypical programming of neuroimmune cells, namely microglia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.