Evidence map›Paper›PMID 30233578›Full record

ArticleFrontiers in immunology2018

Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis.

Georges Abboud, Seung-Chul Choi, Nathalie Kanda, Leilani Zeumer-Spataro, Derry C Roopenian, Laurence Morel

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 134 citations in OpenAlex.

  1. Review
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  10. Energy metabolism in health and diseases.Signal transduction and targeted therapy · 2025
    Review
  11. Review
  12. Article
  13. Review
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  15. Review
  16. Immunometabolic alteration of CD4Clinical and experimental medicine · 2024
    Article
  17. Article
  18. Article
  19. Alpha-ketoglutaric acid based polymeric particles for cutaneous wound healing.Journal of biomedical materials research. Part A · 2023
    Article
  20. Review

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Georges AbboudImmunology, and Laboratory Medicine, Department of Pathology, University of Florida, Gainesville, FL, United States.
Seung-Chul ChoiImmunology, and Laboratory Medicine, Department of Pathology, University of Florida, Gainesville, FL, United States.
Nathalie KandaImmunology, and Laboratory Medicine, Department of Pathology, University of Florida, Gainesville, FL, United States.
Leilani Zeumer-SpataroImmunology, and Laboratory Medicine, Department of Pathology, University of Florida, Gainesville, FL, United States.
Derry C RoopenianThe Jackson Laboratory, Bar Harbor, ME, United States.
Laurence MorelImmunology, and Laboratory Medicine, Department of Pathology, University of Florida, Gainesville, FL, United States.
University of Florida · USJackson Laboratory · US

Funding

Targeting follicular helper CD4 T cells in SLER01AI128901 · NIAID · UNIVERSITY OF FLORIDA · PI MOREL, LAURENCE · 2017 to 2021
$1.8M
NIAID NIH HHS R01 AI128901
6 · The paper itself

Abstract

The K/BxN mouse is a spontaneous model of arthritis driven by T cell receptor transgenic CD4

Indexed as

AnimalsArthritis, RheumatoidAutoantibodiesCD4-Positive T-LymphocytesDeoxyglucoseDisease Models, AnimalDisease ProgressionGerminal CenterGlucose-6-Phosphate IsomeraseGlycolysisHumansJointsMetforminMiceMice, Inbred C57BLMice, Inbred NODAutoantibodiesDeoxyglucoseGlucose-6-Phosphate IsomeraseMetforminReceptors, Antigen, T-Cellarthritisfollicular helper T cellsglycolysismetabolismmouse

Identifiers

PMID30233578
PMCPMC6130222
OpenAlexW2890935099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.