ReviewFrontiers in immunology2018
An Approach to the Evaluation of Persistent Hypereosinophilia in Pediatric Patients.
Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 60 citations in OpenAlex.
- Severe eosinophilia and risk of major disease and mortality: A nationwide cohort study of children and adults.The journal of allergy and clinical immunology. Global · 2026Article
- Assessment of smoking exposure by urine cotinine levels in severe COVID-19 patients: a case-control study.Scientific reports · 2025Observational
- Hypereosinophilia in Children.Current allergy and asthma reports · 2025Review
- Unusual diagnosis in a Lebanese child with persistent hyper eosinophilia: a case report.Annals of medicine and surgery (2012) · 2025Article
- A term infant with severe hypereosinophilia secondary to CMV infection and the STAT1 gene mutation: a case report : List of authors.BMC pediatrics · 2024Article
- Severe Acute Respiratory Distress in a Child with Hypereosinophilic Syndrome: A Case Report.JNMA; journal of the Nepal Medical Association · 2024Article
- Peripheral Blood Eosinophilia in Patients with Diabetic Foot Infection Receiving Long-Term Antibiotic Therapy.Journal of clinical medicine · 2024Article
- Eosinophilia in children: characteristics, etiology and diagnostic algorithm.European journal of pediatrics · 2023Article
- Eosinophilia and Increased Immunoglobulin E: Is It Really a Primary Immunodeficiency? A Diagnostic Challenge.Turkish archives of pediatrics · 2023Article
- Hypereosinophilia in NICU patients with a neonatal lymphatic flow disorder.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Hyperleucocytosis as an unusual presentation of hypereosinophilic pneumonitis with acute respiratory distress syndrome.SAGE open medical case reports · 2022Article
- Pediatric hypereosinophilia and toxoplasma: Peregrination beyond facileness.Journal of family medicine and primary care · 2021Article
- Eosinophil-mediated inflammation in the absence of eosinophilia.Asia Pacific allergy · 2021Review
- Hypereosinophilic Syndrome Masquerading as Complicated Pneumonia.Indian journal of pediatrics · 2020Article
- Eosinophil responses during COVID-19 infections and coronavirus vaccination.The Journal of allergy and clinical immunology · 2020Review
- Childhood asthma in the new omics era: challenges and perspectives.Current opinion in allergy and clinical immunology · 2020Review
- Article
- Pediatric Hypereosinophilia: Characteristics, Clinical Manifestations, and Diagnoses.The journal of allergy and clinical immunology. In practiceArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Hypereosinophilia (HE) is currently defined by a peripheral blood absolute eosinophil count (AEC) of ≥1,500 cells/microL. Although mild blood eosinophilia (AEC 500-1,500 cells/microL) is observed relatively frequently within the pediatric population, persistent HE is uncommon and should prompt additional clinical evaluation. While the clinical manifestations and underlying etiologies of HE in adults have been well-characterized, there is a paucity of data on HE in children. Limited evidence suggests that many similarities between adult and pediatric HE likely exist, but some important differences remain between these populations. The evaluation of HE in children can be challenging given the broad differential diagnosis, which includes primary hematologic disorders and secondary eosinophilia in which the increased eosinophil levels are propagated by disease states that promote eosinophil production and survival. On the basis of the underlying etiology, clinical manifestations can range from benign, self-resolving elevations in the AEC to life-threatening disorders with the potential for significant end-organ damage. Given the broad differential diagnosis of HE, it remains essential to systematically approach the evaluation of unexplained HE in children. This review will discuss the differential diagnosis for pediatric HE, highlighting etiologies that are more prevalent within the pediatric population. Additionally, a summary of the epidemiology of pediatric HE will be presented, with focus on some of the differences that exist between pediatric and adult HE. Finally, a directed approach to the diagnostic evaluation of children with HE will be discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.