Evidence map›Paper›PMID 30233548›Full record

ArticleFrontiers in microbiology2018

An Engineered Synthetic Biologic Protects Against

Gayatri Vedantam, Joshua Kochanowsky, Jason Lindsey, Michael Mallozzi, Jennifer Lising Roxas, Chelsea Adamson, Farhan Anwar, Andrew Clark, Rachel Claus-Walker, Asad Mansoor and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. The Alternative Sigma Factor SigL InfluencesFrontiers in microbiology · 2022
    Article
  7. Review
  8. Expert opinion on therapeutic targets · 2021
    Article
  9. Review
  10. Article
  11. Anti-virulence strategies forGut microbes · 2020
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Gayatri VedantamSchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
Joshua KochanowskyDepartment of Immunobiology, The University of Arizona, Tucson, AZ, United States.
Jason LindseySchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
Michael MallozziSchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
Jennifer Lising RoxasSchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
Chelsea AdamsonSchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
Farhan AnwarSchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
Andrew ClarkSchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
Rachel Claus-WalkerSchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
Asad MansoorSchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
Rebecca McQuadeSchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
Ross Calvin MonaskySchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
Shylaja RamamurthySchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
Bryan RoxasSchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
V K ViswanathanSchool of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.
University of Arizona · USSouthern Arizona VA Health Care System · US

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Teri L Bankhead · 1985 to 2026
$110.2M
MARC/Biomedical Research and Training Program at the University of ArizonaT34GM008718 · NIGMS · UNIVERSITY OF ARIZONA · PI MIRANDA, KATRINA M. · 1999 to 2021
$8.6M
A safe, targeted, designer probiotic to prevent or treat C. difficile infectionR33AI121590 · NIAID · UNIVERSITY OF ARIZONA · PI VEDANTAM, GAYATRI · 2018 to 2020
$1.1M
A safe, targeted, designer probiotic to prevent or treat C. difficile infectionR21AI121590 · NIAID · UNIVERSITY OF ARIZONA · PI VEDANTAM, GAYATRI · 2016 to 2017
$389k
BLRD VA I01 BX001183BLRD VA IK6 BX003789NCI NIH HHS P30 CA023074NIAID NIH HHS R21 AI121590NIAID NIH HHS R33 AI121590NIGMS NIH HHS T34 GM008718
6 · The paper itself

Abstract

Morbidity and mortality attributed to

Indexed as

Clostridium difficileinfectious diarrheaLactobacillussurface layer proteinsynthetic biology

Identifiers

PMID30233548
PMCPMC6134020
OpenAlexW2890588319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.