Evidence map›Paper›PMID 30233521›Full record

ArticleFrontiers in microbiology2018

Interfering With DNA Decondensation as a Strategy Against Mycobacteria.

Enzo M Scutigliani, Edwin R Scholl, Anita E Grootemaat, Sadhana Khanal, Jakub A Kochan, Przemek M Krawczyk, Eric A Reits, Atefeh Garzan, Huy X Ngo, Keith D Green and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. NFrontiers in microbiology · 2024
    Article
  4. Article
  5. Contribution of NmSystems · 2021
    Article
  6. Review
  7. Protein aggregation in bacteria.FEMS microbiology reviews · 2020
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Enzo M ScutiglianiElectron Microscopy Center Amsterdam, Academic Medical Center, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Edwin R SchollElectron Microscopy Center Amsterdam, Academic Medical Center, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Anita E GrootemaatElectron Microscopy Center Amsterdam, Academic Medical Center, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Sadhana KhanalElectron Microscopy Center Amsterdam, Academic Medical Center, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Jakub A KochanMedical Biology, Academic Medical Center, Amsterdam, Netherlands.
Przemek M KrawczykMedical Biology, Academic Medical Center, Amsterdam, Netherlands.
Eric A ReitsMedical Biology, Academic Medical Center, Amsterdam, Netherlands.
Atefeh GarzanDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, United States.
Huy X NgoDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, United States.
Keith D GreenDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, United States.
Sylvie Garneau-TsodikovaDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, United States.
Jan M RuijterMedical Biology, Academic Medical Center, Amsterdam, Netherlands.
Henk A van VeenElectron Microscopy Center Amsterdam, Academic Medical Center, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Nicole N van der WelElectron Microscopy Center Amsterdam, Academic Medical Center, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.
Academic Medical Center · NLUniversity of Kentucky · USAmsterdam University Medical Centers · NLUniversity of Amsterdam · NL

Funding

Novel aminoglycoside adjuvants and stand-alone agents to combat tuberculosisR01AI090048 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARNEAU-TSODIKOVA, SYLVIE · 2011 to 2021
$4.4M
NIAID NIH HHS R01 AI090048
6 · The paper itself

Abstract

Tuberculosis is once again a major global threat, leading to more than 1 million deaths each year. Treatment options for tuberculosis patients are limited, expensive and characterized by severe side effects, especially in the case of multidrug-resistant forms. Uncovering novel vulnerabilities of the pathogen is crucial to generate new therapeutic strategies. Using high resolution microscopy techniques, we discovered one such vulnerability of

Indexed as

antibioticDNA condensationEis inhibitorhigh resolution analysisMycobacterium tuberculosis

Identifiers

PMID30233521
PMCPMC6135046
OpenAlexW2892139348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.