Evidence map›Paper›PMID 30233445›Full record

ArticleFrontiers in psychology2018

Neurochemistry Predicts Convergence of Written and Spoken Language: A Proton Magnetic Resonance Spectroscopy Study of Cross-Modal Language Integration.

Stephanie N Del Tufo, Stephen J Frost, Fumiko Hoeft, Laurie E Cutting, Peter J Molfese, Graeme F Mason, Douglas L Rothman, Robert K Fulbright, Kenneth R Pugh

Open access · goldAbstract read
In one paragraph

Article in Frontiers in psychology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Stephanie N Del TufoDepartment of Special Education, Peabody College, Vanderbilt University, Nashville, TN, United States.
Stephen J FrostHaskins Laboratories, New Haven, CT, United States.
Fumiko HoeftHaskins Laboratories, New Haven, CT, United States.
Laurie E CuttingDepartment of Special Education, Peabody College, Vanderbilt University, Nashville, TN, United States.
Peter J MolfeseHaskins Laboratories, New Haven, CT, United States.
Graeme F MasonDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, United States.
Douglas L RothmanDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, United States.
Robert K FulbrightHaskins Laboratories, New Haven, CT, United States.
Kenneth R PughHaskins Laboratories, New Haven, CT, United States.
Haskins Laboratories · USYale University · USJohn F. Kennedy Center for the Performing Arts · USUniversity of California, San Francisco · USUniversity of Connecticut · US

Funding

Visual word identification: phonology &morphologyP01HD001994 · NICHD · HASKINS LABORATORIES, INC. · PI ZEVIN, JASON D · 1985 to 2016
$23.5M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Tracking neurocognitive changes during evidence-based reading instruction in typically and atypically developing childrenR37HD090153 · NICHD · UNIVERSITY OF CONNECTICUT STORRS · PI Kenneth R. Pugh · 2017 to 2026
$6.0M
Predictors of Non- Response in Young Dyslexic Children with Co-Morbid ADHDP01HD070837 · NICHD · GEORGIA STATE UNIVERSITY · PI ZEVIN, JASON D · 2013 to 2018
$4.6M
Experiential and child factors that determine acquisition of orthographic-phonological regularities in a quasi-regular writing system: An integrated behavioral/computational/neurobiological approachP20HD091013 · NICHD · FLORIDA STATE UNIVERSITY · PI COMPTON, DONALD L · 2017 to 2025
$4.2M
Neural Mechanisms Underlying Compensation in DyslexiaR01HD096261 · NICHD · UNIVERSITY OF CONNECTICUT STORRS · PI HOEFT, FUMIKO · 2018 to 2023
$3.4M
Neurochemistry as a moderator of brain networks for readingR01HD086168 · NICHD · HASKINS LABORATORIES, INC. · PI HOEFT, FUMIKO, PUGH, KENNETH R. · 2016 to 2020
$3.2M
Understanding literacy acquisition through immersion in foreign languagesR01HD078351 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HENDREN, ROBERT LEE, HOEFT, FUMIKO · 2015 to 2020
$3.0M
NICHD NIH HHS P01 HD001994NICHD NIH HHS P01 HD070837NICHD NIH HHS P20 HD091013NICHD NIH HHS R01 HD078351NICHD NIH HHS R01 HD086168NICHD NIH HHS R01 HD096261NICHD NIH HHS R37 HD090153NICHD NIH HHS U54 HD083211
6 · The paper itself

Abstract

Recent studies have provided evidence of associations between neurochemistry and reading (dis)ability (Pugh et al., 2014). Based on a long history of studies indicating that fluent reading entails the automatic convergence of the written and spoken forms of language and our recently proposed Neural Noise Hypothesis (Hancock et al., 2017), we hypothesized that individual differences in cross-modal integration would mediate, at least partially, the relationship between neurochemical concentrations and reading. Cross-modal integration was measured in 231 children using a two-alternative forced choice cross-modal matching task with three language conditions (letters, words, and pseudowords) and two levels of difficulty within each language condition. Neurometabolite concentrations of Choline (Cho), Glutamate (Glu), gamma-Aminobutyric (GABA), and N- acetyl-aspartate (NAA) were then measured in a subset of this sample (

Indexed as

cross-modaldevelopmental dyslexiamagnetic resonance spectroscopy (MRS)multisensoryreadingreading disability (RD)

Identifiers

PMID30233445
PMCPMC6131664
OpenAlexW2890879517

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.