Evidence map›Paper›PMID 30233413›Full record

ArticleFrontiers in physiology2018

Estrogen Therapy Worsens Cardiac Function and Remodeling and Reverses the Effects of Exercise Training After Myocardial Infarction in Ovariectomized Female Rats.

Simone Alves de Almeida, Erick R G Claudio, Vinicius Mengal, Girlandia A Brasil, Eduardo Merlo, Priscila L Podratz, Jones B Graceli, Sonia A Gouvea, Gláucia Rodrigues de Abreu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Sex-Related Effects on Cardiac Development and Disease.Journal of cardiovascular development and disease · 2022
    Review
  8. Review
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Simone Alves de AlmeidaLaboratório de Regulação Neurohumoral da Circulação, Departamento de Ciências Fisiológicas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.
Erick R G ClaudioLaboratório de Regulação Neurohumoral da Circulação, Departamento de Ciências Fisiológicas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.
Vinicius MengalLaboratório de Regulação Neurohumoral da Circulação, Departamento de Ciências Fisiológicas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.
Girlandia A BrasilNúcleo de Pesquisas em Ciências Farmacêuticas - Nupecfarma, Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Vila Velha, Vila Velha, Brazil.
Eduardo MerloDepartamento de Morfologia, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.
Priscila L PodratzDepartamento de Morfologia, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.
Jones B GraceliDepartamento de Morfologia, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.
Sonia A GouveaLaboratório de Regulação Neurohumoral da Circulação, Departamento de Ciências Fisiológicas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.
Gláucia Rodrigues de AbreuLaboratório de Regulação Neurohumoral da Circulação, Departamento de Ciências Fisiológicas, Centro de Ciências da Saúde, Universidade Federal do Espírito Santo, Vitória, Brazil.
Universidade Federal do Espírito Santo · BRUniversidade Vila Velha · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is an increase in the incidence of cardiovascular events such as myocardial infarction (MI) after menopause. However, the use of estrogen therapy (E2) remains controversial. The aim of this study was to evaluate the effects of E2, alone and combined with exercise training (ET), on cardiac function and remodeling in ovariectomized (OVX) rats after MI.

Indexed as

cardiac functionestrogen therapyovariectomyoxidative stressremodeling

Identifiers

PMID30233413
PMCPMC6134041
OpenAlexW2890388554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.