Evidence map›Paper›PMID 30233382›Full record

ArticleFrontiers in physiology2018

Oxidative Stress in the Blood Labyrinthine Barrier in the Macula Utricle of Meniere's Disease Patients.

Gail Ishiyama, Jacob Wester, Ivan A Lopez, Luis Beltran-Parrazal, Akira Ishiyama

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 40 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Morphological studies of labyrinthine tissue in patients affected with Meniere's disease and vestibular schwannoma following labyrinthectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  8. Article
  9. Review
  10. [Association between sleep disorders and vestibular vertigo].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Review
  11. Antioxidants, Hormetic Nutrition, and Autism.Current neuropharmacology · 2024
    Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Untargeted Metabolomic Analysis in Endolymphatic Sac Luminal Fluid from Patients with Meniere's Disease.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Article
  18. Nitrative Stress and Auditory Dysfunction.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Gail IshiyamaDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Jacob WesterDepartment of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Ivan A LopezDepartment of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Luis Beltran-ParrazalDepartment of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Akira IshiyamaDepartment of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
University of California, Los Angeles · US

Funding

The Human Temporal Bone Laboratory Resource for Basic and Applied Inner Ear SciencesU24DC015910 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ISHIYAMA, AKIRA · 2017 to 2022
$4.2M
NIDCD NIH HHS U24 DC015910
6 · The paper itself

Abstract

The blood labyrinthine barrier (BLB) is critical in the maintenance of inner ear ionic and fluid homeostasis. Recent studies using imaging and histopathology demonstrate loss of integrity of the BLB in the affected inner ear of Meniere's disease (MD) patients. We hypothesized that oxidative stress is involved in the pathogenesis of BLB degeneration, and to date there are no studies of oxidative stress proteins in the human BLB. We investigated the ultrastructural and immunohistochemical changes of the BLB in the vestibular endorgan, the macula utricle, from patients with MD (

Indexed as

blood labyrinthine barrierinflammationiNOSMeniere’s diseasenitrotyrosineoxidative stresspericyte migrationvestibular

Identifiers

PMID30233382
PMCPMC6129601
OpenAlexW2889866339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.