Evidence map›Paper›PMID 30233368›Full record

ArticleFrontiers in pharmacology2018

Optimization of the Linker Length of Mannose-Cholesterol Conjugates for Enhanced mRNA Delivery to Dendritic Cells by Liposomes.

Fazhan Wang, Wen Xiao, Mostafa A Elbahnasawy, Xingting Bao, Qian Zheng, Linhui Gong, Yang Zhou, Shuping Yang, Aiping Fang, Mohamed M S Farag and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 57 citations in OpenAlex.

  1. Single-ligand dual-targeting lipid nanoparticles for therapeutic mRNA delivery to glioblastoma across the blood-brain barrier.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Mannose Ligands for Mannose Receptor Targeting.International journal of molecular sciences · 2024
    Review
  9. mRNA vaccines and their delivery strategies: A journey from infectious diseases to cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2024
    Review
  10. Delivery of mRNA with Histidine-Lysine Peptides.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  11. Review
  12. Therapeutic applications of nanobiotechnology.Journal of nanobiotechnology · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. First report on isolation ofBiotechnology reports (Amsterdam, Netherlands) · 2022
    Article
  19. mRNA cancer vaccines: Advances, trends and challenges.Acta pharmaceutica Sinica. B · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Fazhan WangState Key Laboratory of Biotherapy, Geriatrics and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China.
Wen XiaoState Key Laboratory of Biotherapy, Geriatrics and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China.
Mostafa A ElbahnasawyDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Xingting BaoState Key Laboratory of Biotherapy, Geriatrics and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China.
Qian ZhengState Key Laboratory of Biotherapy, Geriatrics and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China.
Linhui GongState Key Laboratory of Biotherapy, Geriatrics and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China.
Yang ZhouState Key Laboratory of Biotherapy, Geriatrics and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China.
Shuping YangState Key Laboratory of Biotherapy, Geriatrics and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China.
Aiping FangState Key Laboratory of Biotherapy, Geriatrics and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China.
Mohamed M S FaragDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Jinhui WuState Key Laboratory of Biotherapy, Geriatrics and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China.
Xiangrong SongState Key Laboratory of Biotherapy, Geriatrics and Cancer Center, West China Hospital, and Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China.
State Key Laboratory of BiotherapySichuan University · CNAl-Azhar University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liposomes (LPs) as commonly used mRNA delivery systems remain to be rationally designed and optimized to ameliorate the antigen expression of mRNA vaccine in dendritic cells (DCs). In this study, we synthesized mannose-cholesterol conjugates (MP

Indexed as

click reactiondendritic cell targeting liposomeslinker lengthmannose conjugatesmRNA vaccine

Identifiers

PMID30233368
PMCPMC6134263
OpenAlexW2889681590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.