Evidence map›Paper›PMID 30233344›Full record

ArticleFrontiers in human neuroscience2018

Neuroimaging Metrics of Drug and Food Processing in Cocaine-Dependence, as a Function of Psychopathic Traits and Substance Use Severity.

William J Denomme, Isabelle Simard, Matthew S Shane

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Psychopathy.Nature reviews. Disease primers · 2021
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Addiction and the Dark Triad of Personality.Frontiers in psychiatry · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

William J DenommeThe Clinical Affective Neuroscience Laboratory for Discovery and Innovation, Faculty of Social Science and Humanities, University of Ontario Institute of Technology, Oshawa, ON, Canada.
Isabelle SimardThe Clinical Affective Neuroscience Laboratory for Discovery and Innovation, Faculty of Social Science and Humanities, University of Ontario Institute of Technology, Oshawa, ON, Canada.
Matthew S ShaneThe Clinical Affective Neuroscience Laboratory for Discovery and Innovation, Faculty of Social Science and Humanities, University of Ontario Institute of Technology, Oshawa, ON, Canada.
University of Ontario Institute of Technology · CAUniversity of New Mexico · US

Funding

Error Detection and Error Awareness in Incarcerated Cocaine Dependent IndividualsR01DA026932 · NIDA · THE MIND RESEARCH NETWORK · PI SHANE, MATTHEW · 2010 to 2015
$1.8M
NIDA NIH HHS R01 DA026932
6 · The paper itself

Abstract

Previous studies suggest that psychopathic traits commonly present as comorbid with substance use disorders. Moreover, neuroimaging and psychometric findings suggest that psychopathic traits may predispose individuals to a sensitized reward response to drugs. Given that substance use disorders are characterized by a neurocognitive bias toward drug-reward relative to non-drug reward, it is possible that heightened psychopathic characteristics may further predispose to this processing bias. To evaluate this possibility, we assessed psychopathic traits (measured using the PCL-R; Hare, 2003) in 105 probationers/parolees and evaluated the relationship between PCL-R scores, lifetime duration of drug use, and biases in neural response to drug- compared to food-related videos. Psychopathic traits (potentially driven by interpersonal/affective traits) were positively correlated with drug > food reactivity within the right insula and left amygdala. In addition, psychopathic traits modulated the relationship between drug use and drug > food reactivity within the left dorsomedial prefrontal cortex, right insula, and left caudate nucleus. Specifically, lifetime duration of drug use correlated positively with drug > food reactivity in participants with lower levels of psychopathic traits and correlated negatively with drug > food reactivity in individuals with higher levels of psychopathic traits. These results help reconcile prior studies on psychopathy and drug-stimulus processing and provide neurocognitive support for the notion that psychopathic traits serve as an underlying risk factor for substance use disorders. These results suggest that different treatment regimens for substance abuse for individuals with higher or lower levels of psychopathy may be beneficial and suggest that reduction of neurocognitive biases to drug-related stimuli may offer useful targets for future treatment protocols.

Indexed as

drug and food processingfMRIneural processingpsychopathyrewardsubstance dependence

Identifiers

PMID30233344
PMCPMC6132024
OpenAlexW2889833375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.