Evidence map›Paper›PMID 30233336›Full record

ArticleFrontiers in behavioral neuroscience2018

Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome.

Samantha Meneely, Mai-Lynne Dinkins, Miki Kassai, Shangru Lyu, Yuning Liu, Chien-Te Lin, Kori Brewer, Yuqing Li, Stefan Clemens

Open access · goldAbstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Putative Animal Models of Restless Legs Syndrome: A Systematic Review and Evaluation of Their Face and Construct Validity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Pooled it
  2. Article
  3. Article
  4. Dopamine receptors and organ fibrosis.Biochemistry and biophysics reports · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Restless Legs Syndrome: Contemporary Diagnosis and Treatment.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Probe the relationship betweenExperimental results · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Samantha MeneelyDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
Mai-Lynne DinkinsDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
Miki KassaiDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
Shangru LyuDepartment of Neurology, College of Medicine, University of Florida, Gainesville, FL, United States.
Yuning LiuDepartment of Neurology, College of Medicine, University of Florida, Gainesville, FL, United States.
Chien-Te LinDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
Kori BrewerDepartment of Emergency Medicine, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
Yuqing LiDepartment of Neurology, College of Medicine, University of Florida, Gainesville, FL, United States.
Stefan ClemensDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
East Carolina University · USUniversity of Florida · USJiangnan University · CN

Funding

Restless Legs Syndrome: Pathophysiology using Btbd9 Conditional Knockout MiceR01NS082244 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING · 2014 to 2018
$1.6M
NINDS NIH HHS R01 NS082244
6 · The paper itself

Abstract

Restless Legs Syndrome (RLS) is often and successfully treated with dopamine receptor agonists that target the inhibitory D3 receptor subtype, however there is no clinical evidence of a D3 receptor dysfunction in RLS patients. In contrast, genome-wide association studies in RLS patients have established that a mutation of the

Indexed as

D1 receptorD3 receptordopamineMeis1RLS animal modelssensorimotor functionspinal cord

Identifiers

PMID30233336
PMCPMC6131574
OpenAlexW2892335157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.