Evidence map›Paper›PMID 30233322›Full record

ArticleFrontiers in cellular neuroscience2018

GSK-3β Inhibitor Alsterpaullone Attenuates MPP

Jiancai Wang, Yuqian Li, Li Gao, Fengqi Yan, Guodong Gao, Lihong Li

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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  5. Genetic analysis of the LRP10 gene in Chinese patients with Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jiancai WangDepartment of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Yuqian LiDepartment of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Li GaoDepartment of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Fengqi YanDepartment of Urology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Guodong GaoDepartment of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Lihong LiDepartment of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
Air Force Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial dysfunction plays significant roles in the pathogenesis of Parkinson's Disease (PD). The inactivation of c-Myc, a down-stream gene of Wnt/β-catenin signaling, may contribute to the mitochondria dysfunction. Inhibition of glycogen synthase kinase 3β (GSK-3β) with Alsterpaullone (Als) can activate the down-stream events of Wnt signaling. Here, we investigated the protective roles of Als against MPP

Indexed as

alsterpaullonec-MycmitochondriaParkinson’s diseasewnt signaling

Identifiers

PMID30233322
PMCPMC6127625
OpenAlexW2888899079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.