ArticleFrontiers in cellular neuroscience2018
AgRP/NPY Neuron Excitability Is Modulated by Metabotropic Glutamate Receptor 1 During Fasting.
Article in Frontiers in cellular neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Adeno-Associated Viral Vectors in the Treatment of Epilepsy.International journal of molecular sciences · 2024Review
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- Regulation of body weight and food intake by AGRP neurons during opioid dependence and abstinence in mice.Frontiers in neural circuits · 2022Article
- Central α-Klotho Suppresses NPY/AgRP Neuron Activity and Regulates Metabolism in Mice.Diabetes · 2020Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
The potential to control feeding behavior via hypothalamic AgRP/NPY neurons has led to many approaches to modulate their excitability-particularly by glutamatergic input. In the present study using NPY-hrGFP reporter mice, we visualize AgRP/NPY neuronal metabotropic glutamate receptor 1 (mGluR1) expression and test the effect of fasting on mGluR1 function. Using the pharmacological agonist dihydroxyphenylglycine (DHPG), we demonstrate the enhanced capacity of mGluR1 to drive firing of AgRP/NPY neurons after overnight fasting, while antagonist 3-MATIDA reduces firing. Further, under synaptic blockade we demonstrate that DHPG acts directly on AgRP/NPY neurons to create a slow inward current. Using an
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