Evidence map›Paper›PMID 30233218›Full record

ArticleStem cells and cloning : advances and applications2018

Sirt1 protects neural stem cells from apoptosis by decreasing acetylation of histone 3K9.

Chongdong Jian, Cuihua Zou, Ning Xu, Guoying Chen, Donghua Zou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells and cloning : advances and applications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Research Progress on the Role of Sirtuin 1 in Cerebral Ischemia.Cellular and molecular neurobiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chongdong JianYoujiang Medical University for Nationalities, Baise, Guangxi 533000, People's Republic of China.
Cuihua ZouYoujiang Medical University for Nationalities, Baise, Guangxi 533000, People's Republic of China.
Ning XuDepartment of Neurology, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, People's Republic of China, danvor0922@hotmail.com.
Guoying ChenDepartment of Neurology, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, People's Republic of China, danvor0922@hotmail.com.
Donghua ZouDepartment of Neurology, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, People's Republic of China, danvor0922@hotmail.com.
Guangxi Medical University · CNAffiliated Hospital of Youjiang Medical University for Nationalities · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the role and mechanism of Sirt1 in protecting neural stem cells (NSCs) from apoptosis. MATERIALS AND

methodsTransfection was used to overexpress Sirt1 in rat NSCs. The effect of Sirt1 overexpression on camptothecin-induced apoptosis of NSCs was evaluated. Western blotting was used to examine the expression of Sirt1, cleaved caspase-3, and acetylated histone 3K9.

resultsOverexpression of Sirt1 in NSCs decreased the cleavage of caspase-3 and acetylation of histone 3K9.

conclusionSirt1 may protect NSCs from apoptosis by decreasing the acetylation of histone 3 on K9.

Indexed as

acetylated histone 3K9apoptosiscaspase-3neural stem cellsSirt1

Identifiers

PMID30233218
PMCPMC6135083
OpenAlexW2891342570

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.