Evidence map›Paper›PMID 30233154›Full record

Trial reportClinical interventions in aging2018

The interactive Physical and Cognitive Exercise System (iPACES™): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers.

Cay Anderson-Hanley, Jessica Stark, Kathryn M Wall, Marisa VanBrakle, Makenzie Michel, Molly Maloney, Nicole Barcelos, Kristina Striegnitz, Brian D Cohen, Arthur F Kramer

3 registry-linked trialsAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical interventions in aging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03069391 naunknown statusnot on this map

The Interactive Physical and Cognitive Exercise System (iPACES™): A Neuro-exergame for Preventing Alzheimer's and Ameliorating Cognitive Impairment

TypeinterventionalSponsorUnion College, New YorkRan2017 to 2022Enrolled31ConditionsAlzheimer Disease, Early Onset, MCI, Aging, Mild Cognitive ImpairmentArmsphysical exercise alone (PES) first, cognitive exercise alone (iCE) first, interactive Physical and Cognitive Exercise (iPACES™)
NCT05009524 naunknown statusnot on this mapstarted 2021, after this paper: background citation

The Interactive Physical and Cognitive Exercise System (iPACES v3) to Benefit Brain Health in Mild Cognitive Impairment (MCI): A Randomized Clinical Trial of Neuro-exergaming Pedal-to-play (iPACES) vs Pedal-while-play (PACE)

TypeinterventionalSponsoriPACES LLCRan2021 to 2022Enrolled120ConditionsMCI, Mild Cognitive Impairment, Alzheimer Disease, DementiaArmsiPACES (interactive Physical and Cognitive Exercise System), PACE (Physical and Cognitive Exercise)
NCT05810454 nanot yet recruitingnot on this mapstarted 2023, after this paper: background citation

Neuro-exergaming for the Prevention and Remediation of Decline Due to Parkinson's Disease: Clinical Trial of the Interactive Physical and Cognitive Exercise System (iPACES-PD)

TypeinterventionalSponsoriPACES LLCRan2023 to 2026Enrolled120ConditionsParkinson's Disease, PD, Mild Cognitive Impairment, MCIArmsiPACES (interactive Physical and Cognitive Exercise System), PACE (Physical and Cognitive Exercise)
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Exergaming for dementia and mild cognitive impairment.The Cochrane database of systematic reviews · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cay Anderson-HanleyHealthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
Jessica StarkHealthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
Kathryn M WallHealthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
Marisa VanBrakleHealthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
Makenzie MichelHealthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
Molly MaloneyHealthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
Nicole BarcelosHealthy Aging & Neuropsychology Lab, Department of Psychology & Neuroscience Program, Union College, Schenectady, NY, USA, andersoc@union.edu.
Kristina StriegnitzComputer Science Department & Neuroscience Program, Union College, Schenectady, NY, USA.
Brian D CohenBiology Department, Union College, Schenectady, NY, USA.
Arthur F KramerCenter for Cognitive & Brain Health, Department of Psychology, Northeastern University, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlzheimer's and related dementias are on the rise, and older adults and their families are seeking accessible and effective ways to stave off or ameliorate mild cognitive impairment (MCI).

aimThis pilot clinical trial (ClinicalTrials.gov Identifier: 03069391) examined neuropsychological and neurobiological outcomes of interactive physical and mental exercise. PARTICIPANTS AND

methodsOlder adults (MCI and caregivers) were enrolled in a 3-month, in-home trial of a portable neuro-exergame (the interactive Physical and Cognitive Exercise System [iPACES™]), in which they pedaled and steered along a virtual bike path to complete a list of errands (Memory Lane™). Neuropsychological function and salivary biomarkers were measured at pre-, mid-, and posttrial. Ten older adults complied with the recommended use of iPACES (complete dose; ≥2×/wk, 67% of the 15 who also had pre- and postevaluation data). Statistical analyses compared change over time and also change among those with a complete dose vs inadequate dose. Correlations between change in neuropsychological and biomarker measures were also examined.

resultsExecutive function and verbal memory increased after 3 months (

conclusionFurther research is needed, but these pilot data provide preliminary indications to suggest neuro-exergaming can impact cognitive function, perhaps via neurobiological mechanisms, and as such may provide an effective and practical way to promote healthy aging.

Indexed as

Video GamesAgedAged, 80 and overBiomarkersCaregiversCognitionCognitive DysfunctionDementiaExecutive FunctionExerciseFemaleHumansHydrocortisoneInsulin-Like Growth Factor IMaleMemoryBiomarkersHydrocortisoneIGF1 protein, humanInsulin-Like Growth Factor Iagingcognitionexecutive functionexergameMCIneuro-exergameneurogame

Identifiers

PMID30233154
PMCPMC6130272

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.