Evidence map›Paper›PMID 30232896›Full record

ArticleOrganic letters2018

Total Synthesis of Asperphenins A and B.

Jia-Lei Yan, Yingying Cheng, Jing Chen, Ranjala Ratnayake, Long H Dang, Hendrik Luesch, Yian Guo, Tao Ye

Abstract read
In one paragraph

Article in Organic letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Sustainable Wacker-Type Oxidations.Angewandte Chemie (International ed. in English) · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jia-Lei YanState Key Laboratory of Chemical Oncogenomics , Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School , Xili, Nanshan District, Shenzhen 518055 , China.
Yingying ChengState Key Laboratory of Chemical Oncogenomics , Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School , Xili, Nanshan District, Shenzhen 518055 , China.
Jing ChenState Key Laboratory of Chemical Oncogenomics , Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School , Xili, Nanshan District, Shenzhen 518055 , China.
Ranjala Ratnayake
Long H Dang
Yian GuoState Key Laboratory of Chemical Oncogenomics , Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School , Xili, Nanshan District, Shenzhen 518055 , China.ORCID 0000-0002-0341-6816
Tao YeState Key Laboratory of Chemical Oncogenomics , Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School , Xili, Nanshan District, Shenzhen 518055 , China.ORCID 0000-0002-2780-9761

Funding

Novel Targeted Anticancer Agents from Marine CyanobacteriaR01CA172310 · NCI · UNIVERSITY OF FLORIDA · PI HENDRIK LUESCH · 2013 to 2026
$5.8M
Development of Complex Natural Product Libraries and Multidimensional Anticancer Screening PlatformsR50CA211487 · NCI · UNIVERSITY OF FLORIDA · PI RATNAYAKE, RANJALA · 2016 to 2020
$440k
NCI NIH HHS R01 CA172310NCI NIH HHS R50 CA211487NIH HHS R01CA172310NIH HHS R50CA211487
6 · The paper itself

Abstract

The first total synthesis of asperphenins A and B has been accomplished in a concise, highly stereoselective fashion from commercially available materials (15 steps, 9.7% and 14.2% overall yields, respectively). The convergent route featured the judicious choice of protecting groups, fragment assembly strategy and a late-stage iron-catalyzed Wacker-type selective oxidation of an internal alkene to the corresponding ketone.

Indexed as

AlkenesAmidesAminesAspergillusCatalysisCycloaddition ReactionKetonesMolecular StructureOxidation-ReductionPalladiumStereoisomerismAlkenesAmidesAminesKetonesPalladium

Identifiers

PMID30232896
PMCPMC7331471

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.