Trial reportJournal of clinical hypertension (Greenwich, Conn.)2018
Acute effects of salt on blood pressure are mediated by serum osmolality.
Trial report in Journal of clinical hypertension (Greenwich, Conn.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Acute effects of salt on blood pressure are mediated by serum osmolality.Journal of clinical hypertension (Greenwich, Conn.) · 2018Trial
- Mechanisms of intrinsic osmolality and sodium detection by magnocellular neurosecretory neurons.Journal of neuroendocrinology · 2025Review
- Monitoring Sodium Intake With a Salt Meter in Hemodialysis Patients.Kidney international reports · 2025Article
- A study on the early metabolic effects of salt and fructose consumption: the protective role of water.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Enhanced peripheral tissue oxygenation and hemoglobin concentration after a high-fat meal measured with spatial frequency domain imaging.Biophotonics discovery · 2024Article
- Salty Subjects: Unpacking Racial Differences in Salt-Sensitive Hypertension.Current hypertension reports · 2024Review
- A new immune disease: systemic hypertension.Clinical kidney journal · 2023Review
- Sugar, salt, immunity and the cause of primary hypertension.Clinical kidney journal · 2023Review
- Altered Neuronal Discharge in the Organum Vasculosum of the Lamina Terminalis Contributes to Dahl Salt-Sensitive Hypertension.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Young Adults with Higher Salt Intake Have Inferior Hydration Status: A Cross-Sectional Study.Nutrients · 2022Article
- An optimal dietary sodium chloride supplemental level of broiler chicks fed a corn-soybean meal diet from 1 to 21 days of age.Frontiers in veterinary science · 2022Article
- Review
- Peak week recommendations for bodybuilders: an evidence based approach.BMC sports science, medicine & rehabilitation · 2021Review
- The Speed of Ingestion of a Sugary Beverage Has an Effect on the Acute Metabolic Response to Fructose.Nutrients · 2021Article
- Lifestyle interventions for the prevention and treatment of hypertension.Nature reviews. Cardiology · 2021Review
- Discrepant acute effect of saline loading on blood pressure, urinary sodium and potassium according to salt intake level: EpiSS study.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Vasopressin mediates fructose-induced metabolic syndrome by activating the V1b receptor.JCI insight · 2021Article
- An update review of intradialytic hypotension: concept, risk factors, clinical implications and management.Clinical kidney journal · 2020Review
- Diabetes Mellitus and Hypertension-A Case of Sugar and Salt?International journal of molecular sciences · 2020Article
- Article
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Authors and funding
12 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is classically thought that it is the amount of salt that is critical for driving acute blood pressure responses. However, recent studies suggest that blood pressure responses, at least acutely, may relate to changes in serum osmolality. Here, we test the hypothesis that acute blood pressure responses to salt can be altered by concomitant water loading. Ten healthy patients free of any disease and medication underwent 4 interventions each a week apart in which they took 300 mL of lentil soup with no salt (visit 1), lentil soup with 3 g salt (visit 2), or lentil soup with 3 g salt and 500 mL water (visit 3) or 750 mL water (visit 4). At each visit, hourly blood measurements and blood pressure measurements (baseline, 1st, 2nd, 3rd, and 4th hour) were performed and plasma osmolarity, sodium and copeptin levels were measured. Patients receiving the 3 g salt showed a 6 mOsm/L change in osmolality with a 2.5 mmol/L change in plasma sodium and 10 mm Hg rise in systolic blood pressure at 2 hours. When the same patients drank salty soup with water, the changes in plasma osmolarity, plasma sodium, and blood pressure were prevented. The ability to raise blood pressure acutely with salt appears dependent on changes in plasma osmolality rather than the amount of salt. Our findings suggest that concurrent intake of water must be considered when evaluating the role of salt in blood pressure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.