Evidence map›Paper›PMID 30232777›Full record

ArticleMolecular neurobiology2019

Diltiazem Promotes Regenerative Axon Growth.

Eric A Huebner, Stéphane Budel, Zhaoxin Jiang, Takao Omura, Tammy Szu-Yu Ho, Lee Barrett, Janie S Merkel, Luis M Pereira, Nick A Andrews, Xingxing Wang and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. A review of new developments in peripheral nerve regeneration.Biochemistry and biophysics reports · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Role of Chondroitin Sulfation Following Spinal Cord Injury.Frontiers in cellular neuroscience · 2020
    Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Eric A HuebnerF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Stéphane BudelCellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.
Zhaoxin JiangCellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.
Takao OmuraF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Tammy Szu-Yu HoF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Lee BarrettF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Janie S MerkelYale Center for Molecular Discovery, Yale University, West Haven, CT, 06516, USA.
Luis M PereiraDepartment of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Nick A AndrewsF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Xingxing WangCellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA.
Bhagat SinghF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Kush KapurF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Michael CostiganF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Stephen M StrittmatterCellular Neuroscience, Neurodegeneration and Repair Program, Departments of Neurology and Neuroscience, Yale University School of Medicine, New Haven, CT, 06520, USA. stephen.strittmatter@yale.edu.
Clifford J WoolfF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA. clifford.woolf@childrens.harvard.edu.ORCID http://orcid.org/0000-0001-9840-596X
Boston Children's Hospital · USYale University · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
Genome-Wide Discovery and Translational Research for Neural RepairR35NS097283 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2017 to 2024
$8.1M
Supplement request for Training GrantT32NS007473 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI Elizabeth C. Engle, Thomas L. Schwarz · 1999 to 2026
$6.9M
MOLECULAR DETERMINANTS OF AXONAL REGENERATIONR01NS039962 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2000 to 2010
$3.9M
Nogo Receptor in Axonal RegenerationR01NS042304 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2001 to 2010
$3.3M
Evaluation of Novel Targets for Retinal Ganglion Cell Axon RegenerationU01EY027256 · NEI · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2016 to 2018
$2.0M
NEURONAL GROWTH CONE SIGNAL TRANSDUCTION MECHANISMSR01NS033020 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 1993 to 2004
$2.0M
NCATS NIH HHS UL1 TR001102NEI NIH HHS U01 EY027256NIGMS NIH HHS T32 GM007205NINDS NIH HHS R01 NS033020NINDS NIH HHS R01 NS039962NINDS NIH HHS R01 NS042304NINDS NIH HHS R35 NS097283NINDS NIH HHS T32 NS007473
6 · The paper itself

Abstract

Axotomy results in permanent loss of function after brain and spinal cord injuries due to the minimal regenerative propensity of the adult central nervous system (CNS). To identify pharmacological enhancers of axon regeneration, 960 compounds were screened for cortical neuron axonal regrowth using an in vitro cortical scrape assay. Diltiazem, verapamil, and bromopride were discovered to facilitate axon regeneration in rat cortical cultures, in the presence of chondroitin sulfate proteoglycans (CSPGs). Diltiazem, an L-type calcium channel blocker (L-CCB), also promotes axon outgrowth in adult primary mouse dorsal root ganglion (DRG) and induced human sensory (iSensory) neurons.

Indexed as

AmidesAnimalsAxonsCalcium Channel BlockersCalcium Channels, L-TypeChondroitin Sulfate ProteoglycansDiltiazemDrug SynergismGanglia, SpinalHumansMice, Inbred C57BLNerve RegenerationPyridinesRats, Sprague-DawleyAmidesCalcium Channel BlockersCalcium Channels, L-TypeChondroitin Sulfate ProteoglycansDiltiazemPyridinesY 27632Axon regenerationChondroitin sulfate proteoglycansCortical neuronsDiltiazemScrape assaySensory neurons

Identifiers

PMID30232777
PMCPMC6424671
OpenAlexW2891906291

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.