Evidence map›Paper›PMID 30232738›Full record

ArticleInternal and emergency medicine2019

Metabolic and vascular effects of silybin in hypertensive patients with high 1-h post-load plasma glucose.

Angela Sciacqua, Maria Perticone, Giovanni Tripepi, Desire Addesi, Velia Cassano, Raffaele Maio, Giorgio Sesti, Francesco Perticone

Abstract read
PubMed Publisher
In one paragraph

Article in Internal and emergency medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Silybin induces endothelium-dependent vasodilation via TRPV4 channels in mouse mesenteric arteries.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Article
  2. Review
  3. Silybin and metabolic disorders.Internal and emergency medicine · 2019
    Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Angela SciacquaDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Campus Universitario di Germaneto, V.le Europa, 88100, Catanzaro, Italy. sciacqua@unicz.it.ORCID http://orcid.org/0000-0003-1674-5317
Maria PerticoneDepartment of Experimental and Clinical Medicine, University Magna Græcia of Catanzaro, Catanzaro, Italy.
Giovanni TripepiCNR-IFC, Istituto di Fisiologia Clinica, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy.
Desire AddesiInternal Medicine Unit, Pugliese-Ciaccio Hospital, Catanzaro, Italy.
Velia CassanoDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Campus Universitario di Germaneto, V.le Europa, 88100, Catanzaro, Italy.
Raffaele MaioDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Campus Universitario di Germaneto, V.le Europa, 88100, Catanzaro, Italy.
Giorgio SestiDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Campus Universitario di Germaneto, V.le Europa, 88100, Catanzaro, Italy.
Francesco PerticoneDepartment of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, Campus Universitario di Germaneto, V.le Europa, 88100, Catanzaro, Italy.
Magna Graecia University · ITAzienda Ospedaliera Pugliese Ciaccio · ITIstituto di Fisiologia Clinica · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertensive patients with normal glucose tolerance (NGT) but 1-h post-load plasma glucose ≥ 155 mg/dl (1-h high), during an oral glucose tolerance test (OGTT), show higher insulin resistance and multiple target organ damages. Experimental and clinical studies demonstrate that silybin presents anti-inflammatory and metabolic effects, improving insulin resistance and endothelial dysfunction. This study aims to evaluate the effects of the complex silybin-vitamin E and phospholipids on inflammatory, metabolic and vascular parameters in NGT 1-h high hypertensive patients. This is a pilot, single arm, interventional, longitudinal study enrolling 50 Caucasian NGT 1-h high hypertensive outpatients, 27 men and 23 women, age range 42-60 years (mean + SD = 52 ± 7). After 6 months of silybin intake, there is a significant improvement in metabolic profile. The glucose response during OGTT significantly improves (AUCglucose

Indexed as

AdultBlood GlucoseDrug CombinationsFemaleGlucose Tolerance TestHumansHypertensionInsulin ResistanceLongitudinal StudiesMaleMiddle AgedPhospholipidsPilot ProjectsProtective AgentsSilybinTreatment OutcomeBlood GlucoseDrug CombinationsPhospholipidsProtective AgentsSilybinVitamin EEssential hypertensionInsulin resistanceSilybinVascular damage

Identifiers

PMID30232738
OpenAlexW2889810110

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.