ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019
Atypical clinical manifestations of Miller Fisher syndrome.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 48 citations in OpenAlex.
- Miller Fisher syndrome: a case report and review of the literature.Journal of medical case reports · 2026Review
- Miller-Fisher Syndrome Presenting With Severe Headache and Transient Loss of Consciousness: A Case Report From Yemen.Clinical medicine insights. Case reports · 2026Article
- Autonomic Dysfunction in Miller Fisher Syndrome: Paralytic Ileus and Isolated Internal Ophthalmoplegia.Internal medicine (Tokyo, Japan) · 2025Article
- Isolated Vertigo as an Early Sign of Anti-GQ1b-Positive Miller Fisher Syndrome: Expanding the Spectrum.Cureus · 2025Article
- A Case of Miller-Fisher Overlap Syndrome With Positive Anti-GM4 Antibody and Atypical Symptoms.Immunity, inflammation and disease · 2025Article
- Frequency of anti-GQ1b IgG antibody in Miller Fisher syndrome: a Chinese single center study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Isolated Ophthalmoplegia as an Atypical Manifestation of Miller Fisher Syndrome Post-viral Conjunctivitis.Cureus · 2025Article
- Miller-Fisher syndrome subtype with isolated bilateral mydriasis: a pediatric case report.BMC neurology · 2025Article
- A Case Report of Anti-GD3 Antibody Positive Incomplete Miller-Fisher Syndrome With Pyramidal Tract Symptoms.Clinical case reports · 2025Article
- Miller-Fisher syndrome presenting with headache and ophthalmoparesis: a case report and literature review.Frontiers in medicine · 2025Article
- Rapid Resolution of Delayed Facial Palsy in Miller Fisher Syndrome With Steroid Therapy.Journal of medical cases · 2024Article
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- Case report on anti-GQ1b antibody syndrome: initial symptoms of pupil palsy and periorbital pain.Frontiers in immunology · 2024Article
- Article
- Clinical Features and Differences of Miller Fisher Syndrome in Southern China: Retrospective Analysis of 72 Patients in 13 Provinces of Southern China.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Anti-GT1a and anti-GQ1b immunoglobulin G antibody positivity with overlapping Miller Fisher/Guillain-Barré syndromes and prominent headache: a case report.The Journal of international medical research · 2023Article
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- Weakness in both lower limbs for 1 week and blepharoptosis for 3 days in a boy aged 1 year and 7 months.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- An Atypical Case of Miller Fisher Syndrome with Multiple Autoimmunity.Neuro-ophthalmology (Aeolus Press) · 2022Article
- Characteristics of pupil palsy in miller-fisher syndrome: case reports and review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Miller Fisher syndrome (MFS) is characterized by a clinical triad of ophthalmoplegia, ataxia, and areflexia, and is closely associated with serum anti-GQ1b antibody. Although the clinical triad is the cardinal diagnostic clue, a variety of other symptoms and signs beyond the triad have been reported. To elucidate the frequency and characteristics of atypical clinical manifestations of MFS, we recruited 38 patients with MFS and evaluated the symptoms or signs beyond the classic triad. Eleven (29%) of 38 patients had atypical clinical manifestations of MFS such as headache (n = 6), delayed facial palsy (n = 3), divergence insufficiency (n = 2), and taste impairment (n = 2). Headache was localized to the periorbital (n = 3), temporal (n = 2), or whole (n = 1) area. Only one of them showed bilateral papilledema and an elevated opening pressure in cerebrospinal fluid analysis. Delayed facial palsy developed after the other signs have reached nadir (n = 1) or started to improve (n = 2), and did not follow a pattern of descending paralysis with other cranial neuropathies. Two patients showed divergence insufficiency without external ophthalmoplegia, and another two had taste impairment over the entire tongue without the other signs of facial and glossopharyngeal nerve involvements. Our study shows that approximately 30% of MFS patients can have atypical clinical manifestations beyond the classic triad. These results reflect the broad clinical spectrum of MFS, and might be associated with the presence of additional antiganglioside antibodies besides anti-GQ1b in patients with MFS.
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