Evidence map›Paper›PMID 30232643›Full record

ArticleJournal of assisted reproduction and genetics2019

Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization.

I Lindgren, H Nenonen, E Henic, L Bungum, A Prahl, M Bungum, I Leijonhufvud, I Huhtaniemi, C Yding Andersen, Y Lundberg Giwercman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Observational
  4. Pharmacogenomic of LH and its receptor: are we ready for clinical practice?Reproductive biology and endocrinology : RB&E · 2025
    Review
  5. Luteinizing Hormone Receptor Mutation (LHRInterdisciplinary sciences, computational life sciences · 2024
    Article
  6. Article
  7. Significance ofInternational journal of reproductive biomedicine · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

I LindgrenDepartment of Translational Medicine, Molecular Genetic Reproductive Medicine, Clinical Research Centre, Lund University, Jan Waldenströms gata 35, Building 91, Plan 10, SE 21428, Malmö, Sweden. Ida.Lindgren@med.lu.se.
H NenonenDepartment of Translational Medicine, Molecular Genetic Reproductive Medicine, Clinical Research Centre, Lund University, Jan Waldenströms gata 35, Building 91, Plan 10, SE 21428, Malmö, Sweden.
E HenicReproductive Medicine Centre, Skåne University Hospital, JanWaldenströms gata 47, Plan 3, SE 21428, Malmö, Sweden.
L BungumDepartment of Obstetrics and Gynecology, Herlev Hospital, Herlev Ringvej 75, 2730, Herlev, Denmark.
A PrahlDepartment of Translational Medicine, Molecular Genetic Reproductive Medicine, Clinical Research Centre, Lund University, Jan Waldenströms gata 35, Building 91, Plan 10, SE 21428, Malmö, Sweden.
M BungumReproductive Medicine Centre, Skåne University Hospital, JanWaldenströms gata 47, Plan 3, SE 21428, Malmö, Sweden.
I LeijonhufvudReproductive Medicine Centre, Skåne University Hospital, JanWaldenströms gata 47, Plan 3, SE 21428, Malmö, Sweden.
I HuhtaniemiHammersmith Campus, Institute of Reproductive and Developmental Biology, Imperial College London, London, SW7 2AZ, UK.
C Yding AndersenLaboratory of Reproductive Biology, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark.
Y Lundberg GiwercmanDepartment of Translational Medicine, Molecular Genetic Reproductive Medicine, Clinical Research Centre, Lund University, Jan Waldenströms gata 35, Building 91, Plan 10, SE 21428, Malmö, Sweden.
Lund University · SESkåne University Hospital · SEHerlev Hospital · DKImperial College London · GBRigshospitalet · DK

Funding

ALF governments grant F2014/354Interreg V, EU 20200407
6 · The paper itself

Abstract

purposeThe objective was to investigate if the gonadotropin receptor variants N680S (N: asparagine, S: serine, rs6166) in the follicle-stimulating hormone receptor (FSHR) and N312S (rs2293275) in the luteinizing hormone/human chorionic gonadotropin receptor (LHCGR) predicted cumulative live birth rate after in vitro fertilization (IVF).

methodsA total of 665 women were consecutively enrolled for IVF during the period 2007-2016. Inclusion criteria were < 40 years of age, body mass index < 30 kg/m

resultsWomen homozygous for S in both receptors combined (4S) had significantly higher live birth rate compared to those with other receptor variants when combining the first three IVF cycles (OR = 2.00, 95% CI [1.02, 3.92], p = 0.043). Cumulatively higher chance of live birth rate, during all IVF cycles, was also evident (HR = 1.89, 95% CI [1.00, 3.57], p = 0.049).

conclusionsGonadotropin receptor variants are promising candidates for the prediction of the possibility to have a baby to take home after IVF treatment.

Indexed as

Birth RateFertilization in VitroPolymorphism, GeneticAdultFemaleHumansLive BirthPregnancyPregnancy RateReceptors, FSHReceptors, LHTreatment OutcomeFSHR protein, humanReceptors, FSHReceptors, LHFSH receptorInfertilityIn vitro fertilizationLHCG receptorPolymorphism

Identifiers

PMID30232643
PMCPMC6338601
OpenAlexW2892276691

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.