Evidence map›Paper›PMID 30232624›Full record

ArticleClinical oral investigations2019

Metallic crown-induced occlusal trauma as a protocol to evaluate inflammatory response in temporomandibular joint and periodontal tissues of rats.

Henrique Ballassini Abdalla, Juliana Trindade Clemente-Napimoga, Ricardo Bonfante, Caio Augusto Hashizume, Wilian Segatto Zanelli, Cristina Gomes de Macedo, Marcelo Henrique Napimoga, Wilkens Aurélio Buarque E Silva, Frederico Andrade E Silva

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Article in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Henrique Ballassini AbdallaDepartment of Physiology Sciences, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, São Paulo, Brazil.
Juliana Trindade Clemente-NapimogaSão Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 - Swift, Campinas, São Paulo, Brazil. juliana.napimoga@slmandic.edu.br.
Ricardo BonfanteDepartment of Physiology Sciences, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, São Paulo, Brazil.
Caio Augusto HashizumeDepartment of Physiology Sciences, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, São Paulo, Brazil.
Wilian Segatto ZanelliDepartment of Physiology Sciences, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, São Paulo, Brazil.
Cristina Gomes de MacedoSão Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 - Swift, Campinas, São Paulo, Brazil.
Marcelo Henrique NapimogaSão Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 - Swift, Campinas, São Paulo, Brazil.
Wilkens Aurélio Buarque E SilvaDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, São Paulo, Brazil.
Frederico Andrade E SilvaDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, São Paulo, Brazil.
Universidade Estadual de Campinas (UNICAMP) · BRFaculdade São Leopoldo Mandic · BR

Funding

National Council for Scientific and Technological Development (CNPq), Brazil 308119/2017-7
6 · The paper itself

Abstract

objectivesThe goal of this study is to propose a standard protocol of experimental occlusal trauma to evaluate the inflammatory hyperalgesia induced by metallic crowns on orofacial tissues of rats. MATERIALS AND

methodsThirty animals were randomly divided into six groups (n = 5 per group). Detailed methodology on the manufacturing of metallic crowns is described. The inflammatory hyperalgesia induced by occlusal interference was evaluated by intra-articular injection of a low dose of 0.5% formalin (30 μl) or vehicle (saline) into temporomandibular joint, 21 or 28 days after metallic crown cementation. Posteriorly, pro-inflammatory cytokines were evaluated by enzyme-linked immunosorbent assay to assess the effect of occlusal interference on periodontium.

resultsThe cementation of metallic crowns with dental anatomy on the lower molar of rats does not show signs of stress and lack of feeding. Metallic crown-induced occlusal trauma results in a temporomandibular joint inflammatory hyperalgesia (P < 0.05: ANOVA, Tukey's test). Otherwise, it was observed that occlusal trauma results in the increase of protein level of pro-inflammatory cytokines TNF-alpha and IL-1beta in the gingival tissues (P < 0.05).

conclusionThis study demonstrates in detail a methodology of occlusal trauma resulting from the cementation of metallic crowns in the lower molars of rats, mimicking occlusal interferences commonly evaluated in the dental clinic. This methodology makes new studies to better understand the mechanisms involved in the occlusal trauma of orofacial tissues possible. CLINICAL RELEVANCE: The standardization of an experimental occlusal interference model will allow us to understand the deleterious effect and mechanisms that affect the orofacial tissues.

Indexed as

CrownsDental Occlusion, TraumaticInflammationAnimalsCytokinesHyperalgesiaMalePeriodontiumRandom AllocationRatsRats, WistarTemporomandibular JointCytokinesExperimental occlusal interferenceHyperalgesiaInflammationOcclusal traumaPeriodontal tissuesTemporomandibular disorders

Identifiers

PMID30232624
OpenAlexW2891445177

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.