Evidence map›Paper›PMID 30232520›Full record

ArticleCancer immunology, immunotherapy : CII2019

Sustained efficacy of adjuvant immunotherapy with cytokine-induced killer cells for hepatocellular carcinoma: an extended 5-year follow-up.

Jeong-Hoon Lee, Joon Hyeok Lee, Young-Suk Lim, Jong Eun Yeon, Tae-Jin Song, Su Jong Yu, Geum-Youn Gwak, Kang Mo Kim, Yoon Jun Kim, Jae Won Lee and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 4 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 4 syntheses or guidelines pooled it, 89 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Jeong-Hoon LeeDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.ORCID http://orcid.org/0000-0002-0315-2080
Joon Hyeok LeeDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.ORCID http://orcid.org/0000-0003-3547-7434
Young-Suk LimDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.ORCID http://orcid.org/0000-0002-1544-577X
Jong Eun YeonThe Liver Center, Korea University Guro Hospital, Seoul, South Korea.ORCID http://orcid.org/0000-0002-0510-7371
Tae-Jin SongDepartment of Surgery, Korea University Ansan Hospital, Ansan, Gyeonggi-do, South Korea.ORCID http://orcid.org/0000-0001-9278-812X
Su Jong YuDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.ORCID http://orcid.org/0000-0001-8888-7977
Geum-Youn GwakDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.ORCID http://orcid.org/0000-0002-6453-3450
Kang Mo KimDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.ORCID http://orcid.org/0000-0002-3180-3178
Yoon Jun KimDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.ORCID http://orcid.org/0000-0001-9141-7773
Jae Won LeeDepartment of Statistics, Korea University, Seoul, South Korea.ORCID http://orcid.org/0000-0002-3718-2704
Jung-Hwan YoonDepartment of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea. yoonjh@snu.ac.kr.ORCID http://orcid.org/0000-0002-9128-3610
Seoul National University · KRStatistics Korea · KRUlsan College · KRKorea University · KRKorea University Medical Center · KRSamsung Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our earlier multicenter randomized controlled trial showed that adjuvant immunotherapy with cytokine-induced killer (CIK) cells resulted in longer recurrence-free survival (RFS) and overall survival (OS) as well in patients who received curative treatment for hepatocellular carcinoma (HCC). In the present study, we determined if the efficacy of CIK cell therapy continued after end of repeated CIK cell injections. We performed a follow-up study of our preceding trial. We included 226 patients: 114 patients in the immunotherapy group (injection of 6.4 × 10

Indexed as

AgedCarcinoma, HepatocellularCytokine-Induced Killer CellsFemaleFollow-Up StudiesHumansImmunotherapy, AdoptiveKaplan-Meier EstimateLiver NeoplasmsMaleMiddle AgedNeoplasm Recurrence, LocalOutcome Assessment, Health CareProportional Hazards ModelsTime FactorsAdjuvant immunotherapyCytokine-induced killer cellHepatocellular carcinomaOverall survivalRecurrence-free survival

Identifiers

PMID30232520
PMCPMC6326973
OpenAlexW2890494395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.