SynthesisScientific reports2018
The human gut pan-microbiome presents a compositional core formed by discrete phylogenetic units.
Synthesis in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Distinct Features Based on Partitioning of the Endophytic Fungi of Cereals and Other Grasses.Microbiology spectrum · 2023Pooled it
- Article
- Managing Gut Dysbiosis: Clinical Evidence and Perspectives onMicroorganisms · 2026Review
- Exploring the role of infectious pathogens in Alzheimer's disease neuroinflammation.Frontiers in cellular and infection microbiology · 2026Review
- Article
- Gut microbiota signatures of the three Mexican primate species, including hybrid populations.PloS one · 2025Article
- Selective shaping of prokaryotic communities and core symbiont maintenance suggest large-scale aquarium facilities as reservoirs of microbiome diversity in octocorals.Frontiers in microbiology · 2025Article
- Understanding dysbiosis and resilience in the human gut microbiome: biomarkers, interventions, and challenges.Frontiers in microbiology · 2025Review
- Article
- Chronic kidney disease and gut microbiota.Heliyon · 2023Review
- Leveraging phylogenetic signal to unravel microbiome function and assembly rules.Computational and structural biotechnology journal · 2023Article
- Islet autoantibody seroconversion in type-1 diabetes is associated with metagenome-assembled genomes in infant gut microbiomes.Nature communications · 2022Article
- Exploring the universal healthy human gut microbiota around the World.Computational and structural biotechnology journal · 2022Article
- Microbial characteristics of dental caries in HIV positive individuals.Frontiers in oral health · 2022Article
- Article
- Assessment of phylo-functional coherence along the bacterial phylogeny and taxonomy.Scientific reports · 2021Article
- Article
- A comprehensive human minimal gut metagenome extends the host's metabolic potential.Microbial genomics · 2020Article
- Longitudinal gut microbiome changes in alcohol use disorder are influenced by abstinence and drinking quantity.Gut microbes · 2020Article
- Challenges and emerging systems biology approaches to discover how the human gut microbiome impact host physiology.Biophysical reviews · 2020Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complex community of microbes living in the human gut plays an important role in host wellbeing. However, defining a 'healthy' gut microbiome in terms of composition has remained an elusive task, despite its anticipated medical and scientific importance. In this regard, a central question has been if there is a 'core' microbiome consisting of bacterial groups common to all healthy humans. Recent studies have been able to define a compositional core in human gut microbiome datasets in terms of taxonomic assignments. However, the description of the core microbiome in terms of taxonomic assignments may not be adequate when considering subsequent analyses and applications. Through the implementation of a dynamic clustering approach in the meta-analyisis of comprehensive 16S rRNA marker gene datasets, this study found that the human gut pan-microbiome presents a preeminent compositional core comprised of discrete units of varying phylogenetic depth present in all individuals studied. Since both microbial traits and ecological coherence show signs of phylogenetic conservation, this outcome provides a new conceptual framework in the study of the ecosystem, as well as important practical considerations which should be taken into account in future research.
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Registered trials
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