Evidence map›Paper›PMID 30232424›Full record

ArticleNature2018

Evidence that CD32a does not mark the HIV-1 latent reservoir.

Christa E Osuna, So-Yon Lim, Jessica L Kublin, Richard Apps, Elsa Chen, Talia M Mota, Szu-Han Huang, Yanqin Ren, Nathaniel D Bachtel, Athe M Tsibris and 4 more

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed.

  1. FcγRIIIa is a noncanonical costimulatory molecule for CD8 T cells.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Review
  3. Review
  4. Effective and targeted latency reversal in CD4Emerging microbes & infections · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. CD32iScience · 2021
    Article
  13. Review
  14. Review
  15. Review
  16. CD32Frontiers in immunology · 2021
    Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Christa E OsunaCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
So-Yon LimCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Jessica L KublinCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Richard AppsCenter for Human Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Elsa ChenCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Talia M MotaDivision of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Szu-Han HuangDivision of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Yanqin RenDivision of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Nathaniel D BachtelDivision of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Athe M TsibrisBrigham and Women's Hospital, Boston, Massachusetts Harvard Medical School, Boston, MA, USA.
Margaret E AckermanThayer School of Engineering, Dartmouth College, Hanover, NH, USA.
R Brad JonesDivision of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
Douglas F NixonDivision of Infectious Diseases, Weill Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
James B WhitneyCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. jwhitne2@bidmc.harvard.edu.

Funding

BELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral EradicationUM1AI126617 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JONES, R. BRAD, NIXON, DOUGLAS F · 2016 to 2020
$28.1M
Multidisciplinary HIV Training ProgramT32AI007387 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel R. Kuritzkes · 1990 to 2026
$8.8M
Viral dynamics of rebound and control following early treatment of HIV/SIVP01AI131365 · NIAID · BOSTON COLLEGE · PI WHITNEY, JAMES BURTON · 2017 to 2021
$7.5M
TLR Immunotherapy to Eradicate Anatomic SIV ReservoirsR01AI127089 · NIAID · BOSTON COLLEGE · PI WHITNEY, JAMES BURTON · 2016 to 2020
$3.5M
Mechanisms of SIV persistenceR56AI091514 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WHITNEY, JAMES BURTON · 2011 to 2011
$849k
TLR Therapy to Eradicate the SIV ReservoirR56AI122942 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WHITNEY, JAMES BURTON · 2016 to 2016
$738k
NIAID NIH HHS P01 AI131365NIAID NIH HHS R01 AI127089NIAID NIH HHS R56 AI091514NIAID NIH HHS R56 AI122942NIAID NIH HHS T32 AI007387NIAID NIH HHS UM1 AI126617
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID30232424
PMCPMC6528470

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.