ArticleScientific reports2018
Child Weight Gain Trajectories Linked To Oral Microbiota Composition.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01167270 (The Intervention Nurses Start Infants Growing on Healthy Trajectories), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Intervention Nurses Start Infants Growing on Healthy Trajectories (INSIGHT) Study
Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diet, adiposity, and the gut microbiota from infancy to adolescence: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Association of PCR-based oral bacterial profiles with fluorescence-detected plaque and caries experience in 3-year-old children: a cross-sectional study.BMC oral health · 2026Article
- Oral health assessment in a prospective birth cohort study.BDJ open · 2026Article
- Distinct oral and fecal microbiota composition in preschool children with overweight/obesity: a cross-sectional study.Applied microbiology and biotechnology · 2026Article
- Effects of cigarette smoking on the oral microbiome in adolescents.Scientific reports · 2026Article
- The association of oral microbiota and oral-gut microbial co-presence with obesity in Chinese children.Frontiers in cellular and infection microbiology · 2026Article
- Shaping oral and intestinal microbiota and the immune system during the first 1,000 days of life.Frontiers in pediatrics · 2025Review
- Differential effects of high-fat diet on salivary and gut microbiota.Frontiers in cellular and infection microbiology · 2025Article
- Burden of oral diseases predicts development of excess weight in early adolescence: a 2-year longitudinal study.European journal of pediatrics · 2024Article
- Methylation profiles at birth linked to early childhood obesity.Journal of developmental origins of health and disease · 2024Article
- Early life factors and oral microbial signatures define the risk of caries in a Swedish cohort of preschool children.Scientific reports · 2024Article
- Characterization of oral microbiota in 6-8-month-old small breed dogs.BMC veterinary research · 2024Article
- Methylation profiles at birth linked to early childhood obesity.medRxiv : the preprint server for health sciences · 2024Article
- The potential of including the microbiome as biomarker in population-based health studies: methods and benefits.Frontiers in public health · 2024Review
- Comparison of intestinal and pharyngeal microbiota in preterm infants on the first day of life and the characteristics of pharyngeal microbiota in infants delivered by cesarean section or vaginally.Frontiers in pediatrics · 2024Article
- The association of tonsillar microbiota with biochemical indices based on obesity and tonsillar hypertrophy in children.Scientific reports · 2023Article
- Maternal and infant microbiome: next-generation indicators and targets for intergenerational health and nutrition care.Protein & cell · 2023Review
- Systemic and Oral Health Parameters in Eutrophic and Overweight/Obese Adolescents: A Cross-Sectional Study.Journal of personalized medicine · 2023Article
- The role of the oral microbiome in obesity and metabolic disease: potential systemic implications and effects on taste perception.Nutrition journal · 2023Review
- Role of oral and gut microbiota in childhood obesity.Folia microbiologica · 2023Review
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12 authors.
Funding
Abstract
Gut and oral microbiota perturbations have been observed in obese adults and adolescents; less is known about their influence on weight gain in young children. Here we analyzed the gut and oral microbiota of 226 two-year-olds with 16S rRNA gene sequencing. Weight and length were measured at seven time points and used to identify children with rapid infant weight gain (a strong risk factor for childhood obesity), and to derive growth curves with innovative Functional Data Analysis (FDA) techniques. We showed that growth curves were associated negatively with diversity, and positively with the Firmicutes-to-Bacteroidetes ratio, of the oral microbiota. We also demonstrated an association between the gut microbiota and child growth, even after controlling for the effect of diet on the microbiota. Lastly, we identified several bacterial genera that were associated with child growth patterns. These results suggest that by the age of two, the oral microbiota of children with rapid infant weight gain may have already begun to establish patterns often seen in obese adults. They also suggest that the gut microbiota at age two, while strongly influenced by diet, does not harbor obesity signatures many researchers identified in later life stages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.