Evidence map›Paper›PMID 30232371›Full record

ArticleNPJ schizophrenia2018

The language profile of formal thought disorder.

Derya Çokal, Gabriel Sevilla, William Stephen Jones, Vitor Zimmerer, Felicity Deamer, Maggie Douglas, Helen Spencer, Douglas Turkington, Nicol Ferrier, Rosemary Varley and 2 more

Open access · goldAbstract read
In one paragraph

Article in NPJ schizophrenia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 74 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Linking spontaneous speech, cognition, and psychopathology across affective and psychotic disorders: A network approach.European psychiatry : the journal of the Association of European Psychiatrists · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. A single composite index of semantic behavior tracks symptoms of psychosis over time.medRxiv : the preprint server for health sciences · 2025
    Article
  13. Trajectories through semantic spaces in schizophrenia and the relationship to ripple bursts.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Derya ÇokalInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK. deryacokal@gmail.com.
Gabriel SevillaDepartment of Translation and Language Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
William Stephen JonesInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Vitor ZimmererDepartment of Language and Cognition, University College London, London, UK.
Felicity DeamerDepartment of Philosophy, Durham University, Durham, UK.
Maggie DouglasInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Helen SpencerInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Douglas TurkingtonInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Nicol FerrierInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Rosemary VarleyDepartment of Language and Cognition, University College London, London, UK.
Stuart WatsonInstitute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0002-2558-3367
Wolfram HinzenDepartment of Translation and Language Sciences, Universitat Pompeu Fabra, Barcelona, Spain.
Cumbria Northumberland Tyne and Wear NHS Foundation Trust · GBDurham University · GBNewcastle University · GBUniversity College London · GBInstitució Catalana de Recerca i Estudis Avançats · ESUniversitat Pompeu Fabra · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Formal thought disorder (FTD) is clinically manifested as disorganized speech, but there have been only few investigations of its linguistic properties. We examined how disturbance of thought may relate to the referential function of language as expressed in the use of noun phrases (NPs) and the complexity of sentence structures. We used a comic strip description task to elicit language samples from 30 participants with schizophrenia (SZ), 15 with moderate or severe FTD (SZ + FTD), and 15 minimal or no FTD (SZ-FTD), as well as 15 first-degree relatives of people with SZ (FDRs) and 15 neurotypical controls (NC). We predicted that anomalies in the normal referential use of NPs, sub-divided into definite and indefinite NPs, would identify FTD; and also that FTD would also be linked to reduced linguistic complexity as specifically measured by the number of embedded clauses and of grammatical dependents. Participants with SZ + FTD produced more referential anomalies than NC and produced the fewest definite NPs, while FDRs produced the most and thus also differed from NC. When referential anomalies were classed according to the NP type in which they occurred, the SZ + FTD group produced more anomalies in definite NPs than NC. Syntactic errors did not distinguish groups, but the SZ + FTD group exhibited significantly less syntactic complexity than non-SZ groups. Exploratory regression analyses suggested that production of definite NPs distinguished the two SZ groups. These results demonstrate that FTD can be identified in specific grammatical patterns which provide new targets for detection, intervention, and neurobiological studies.

Identifiers

PMID30232371
PMCPMC6145886
OpenAlexW2891150581

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.