ArticleJCI insight2018
Gluconeogenesis and risk for fasting hyperglycemia in Black and White women.
Article in JCI insight, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Ectopic fat deposition in populations of black African ancestry: A systematic review and meta-analysis.Acta diabetologica · 2022Pooled it
- Validation in adult Black and White women of the ISS model for estimating insulin sensitivity and beta-cell function from mixed-meal tests.American journal of physiology. Endocrinology and metabolism · 2026Article
- Paving the way for improved action: how nuclear techniques can advance the assessment of malnutrition.The American journal of clinical nutrition · 2025Article
- Prediabetes.Nature reviews. Disease primers · 2025Review
- Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney, and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways.World journal of diabetes · 2024Article
- The association of a healthy lifestyle index and imaging-based body fat distribution with glycemic status and Type 2 diabetes in the Multi Ethnic Cohort: a cross-sectional analysis.European journal of clinical nutrition · 2024Article
- Phthalates and Incident Diabetes in Midlife Women: The Study of Women's Health Across the Nation (SWAN).The Journal of clinical endocrinology and metabolism · 2023Article
- Excessive gluconeogenesis causes the hepatic insulin resistance paradox and its sequelae.Heliyon · 2022Review
- Pathophysiology of type 2 diabetes in sub-Saharan Africans.Diabetologia · 2022Review
- Body Fat Distribution, Glucose Metabolism, and Diabetes Status Among Older Adults: The Multiethnic Cohort Adiposity Phenotype Study.Journal of epidemiology · 2022Article
- Article
- Synergizing Mouse and Human Studies to Understand the Heterogeneity of Obesity.Advances in nutrition (Bethesda, Md.) · 2021Review
- Renal gluconeogenesis in insulin resistance: A culprit for hyperglycemia in diabetes.World journal of diabetes · 2021Review
- Diet and Fat Metabolism-Uncovering Key Determinants of Diabetes Risk Prediction in Populations of African Descent.The Journal of clinical endocrinology and metabolism · 2021Article
- The OGTT is highly reproducible in Africans for the diagnosis of diabetes: Implications for treatment and protocol design.Diabetes research and clinical practice · 2020Article
- Metformin improves blood glucose by increasing incretins independent of changes in gluconeogenesis in youth with type 2 diabetes.Diabetologia · 2020Observational
- Triglyceride Paradox Is Related to Lipoprotein Size, Visceral Adiposity and Stearoyl-CoA Desaturase Activity in Black Versus White Women.Circulation research · 2020Article
- A Review of Diabetes Prediction Equations in African Descent Populations.Frontiers in endocrinology · 2019Review
- Scutellariae Radix and Coptidis Rhizoma Improve Glucose and Lipid Metabolism in T2DM Rats via Regulation of the Metabolic Profiling and MAPK/PI3K/Akt Signaling Pathway.International journal of molecular sciences · 2018Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
Abstract
Black women, compared with White women, have high rates of whole-body insulin resistance but a lower prevalence of fasting hyperglycemia and hepatic steatosis. This dissociation of whole-body insulin resistance from fasting hyperglycemia may be explained by racial differences in gluconeogenesis, hepatic fat, or tissue-specific insulin sensitivity. Two groups of premenopausal federally employed women, without diabetes were studied. Using stable isotope tracers, [2H2O] and [6,62-H2]glucose, basal glucose production was partitioned into its components (gluconeogenesis and glycogenolysis) and basal whole-body lipolysis ([2H5]glycerol) was measured. Indices of insulin sensitivity, whole-body (SI), hepatic (HISIGPR), and adipose tissue, were calculated. Hepatic fat was measured by proton magnetic resonance spectroscopy. Black women had less hepatic fat and lower fractional and absolute gluconeogenesis. Whole-body SI, HISIGPR, and adipose tissue sensitivity were similar by race, but at any given level of whole-body SI, Black women had higher HISIGPR. Therefore, fasting hyperglycemia may be a less common early pathological feature of prediabetes in Black women compared with White women, because gluconeogenesis remains lower despite similar whole-body SI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.