ArticleNeurology2018
Changes in subjective experience elicited by direct stimulation of the human orbitofrontal cortex.
Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural bases of the bodily self as revealed by electrical brain stimulation: A systematic review.Human brain mapping · 2023Pooled it
- Stimulating and Recording Brain Signals in an Olfactory Context: Non-Canonical Brain Structures May Contribute to Olfactory Processing - A Case Series.Brain topography · 2026Article
- Symptomatic Emotional Responses and Changes in Networks Elicited by Direct Electrical Stimulation.CNS neuroscience & therapeutics · 2025Article
- Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices.Nature communications · 2024Article
- "Amity Seizures": A previously unreported semiology localizing to a circuit between the right hippocampus and orbitofrontal area.Epilepsy & behavior reports · 2024Article
- Uncovering the fast, directional signal flow through the human temporal pole during semantic processing.Scientific reports · 2023Article
- Causally mapping human threat extinction relevant circuits with depolarizing brain stimulation methods.Neuroscience and biobehavioral reviews · 2023Review
- Towards causal mechanisms of consciousness through focused transcranial brain stimulation.Neuroscience of consciousness · 2023Review
- Analysis of lateral orbitofrontal cortex activation on acquisition of fear extinction and neuronal activities in fear circuit.Brain structure & function · 2022Article
- Association of increased abdominal adiposity at birth with altered ventral caudate microstructure.International journal of obesity (2005) · 2021Article
- Abnormal connectivity of anterior-insular subdivisions and relationship with somatic symptom in depressive patients.Brain imaging and behavior · 2021Article
- Disrupting self-evaluative processing with electrostimulation mapping during awake brain surgery.Scientific reports · 2021Article
- Endogenous variation in ventromedial prefrontal cortex state dynamics during naturalistic viewing reflects affective experience.Science advances · 2021Article
- Does the Prefrontal Cortex Play an Essential Role in Consciousness? Insights from Intracranial Electrical Stimulation of the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Prevalence and correlates of parosmia and phantosmia among smell disorders.Chemical senses · 2021Article
- Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Insights into human cognition from intracranial EEG: A review of audition, memory, internal cognition, and causality.Journal of neural engineering · 2020Review
- Forced conceptual thought induced by electrical stimulation of the left prefrontal gyrus involves widespread neural networks.Epilepsy & behavior : E&B · 2020Observational
- Intensity of affective experience is modulated by magnitude of intracranial electrical stimulation in human orbitofrontal, cingulate and insular cortices.Social cognitive and affective neuroscience · 2019Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe applied direct cortical stimulation (DCS) to the orbitofrontal cortex (OFC) in neurosurgical patients implanted with intracranial electrodes to probe, with high anatomic precision, the causal link between the OFC and human subjective experience.
methodsWe administered 272 instances of DCS at 172 OFC sites in 22 patients with intractable focal epilepsy (from 2011 to 2017), none of whom had seizures originating from the OFC.
resultsOur observations revealed a rich variety of affective, olfactory, gustatory, and somatosensory changes in the subjective domain. Elicited experiences were largely neutral or negatively valenced (e.g., aversive smells and tastes, sadness, and anger). Evidence was found for preferential left lateralization of negatively valenced experiences and strong right lateralization of neutral effects. Moreover, most of the elicited effects were observed after stimulation of OFC tissue around the transverse orbital sulcus, and none were seen in the most anterior aspects of the OFC.
conclusionsOur study yielded 3 central findings: first, a dissociation between the "silent" anterior and nonsilent middle/posterior OFC where stimulation clearly elicits changes in subjective experience; second, evidence that the OFC might play a causal role in integrating affect and multimodal sensory experiences; and third, clear evidence for left lateralization of negatively valenced effects. Our findings provide important information for clinicians treating OFC injury or planning OFC resection and scientists seeking to understand the brain basis for the integration of sensation, cognition, and affect.
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