Evidence map›Paper›PMID 30232205›Full record

ArticleBMJ case reports2018

Unusual case of levamisole-induced dual-positive ANCA vasculitis and crescentic glomerulonephritis.

Dileep Kumar, Ibrahim Batal, Belinda Jim, Barbara Mendez, Kisra Anis

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dileep KumarDepartment of Medicine, Jacobi Medical Center, Bronx, New York, USA.
Ibrahim BatalDepartment of Pathology, NewYork-Presbyterian Hospital, New York, New York, USA.
Belinda JimDepartment of Medicine, Jacobi Medical Center, Bronx, New York, USA.
Barbara MendezDepartment of Medicine, Jacobi Medical Center, Bronx, New York, USA.
Kisra AnisDepartment of Medicine, Jacobi Medical Center, Bronx, New York, USA.
Jacobi Medical Center · USNew York Hospital Queens · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cocaine adulterated levamisole is an increasingly reported cause of skin necrosis, arthralgia and systemic vasculitis, but renal involvement is uncommon. We present a case of a 40-year-old Hispanic man with a history of cocaine abuse who presented with acute kidney injury to the rheumatology clinic where he was being treated for chronic inflammatory arthritis. He was found to have a serum creatinine of 2.5 mg/dL, microscopic haematuria and subnephrotic proteinuria, along with positive proteinase 3, myeloperoxidase, anticardiolipin antibodies and an elevated antinuclear antibody titre. The renal pathology revealed focal necrotising glomerulonephritis with crescentic features and mild immune type deposition. The patient was treated with cocaine abstinence, pulse dose steroids followed by maintenance prednisone, rituximab and cyclophosphamide. His renal function subsequently improved but did not normalise. We believe that his incomplete improvement was due to the degree of kidney injury on presentation as well as recidivism with cocaine use.

Indexed as

Acute Kidney InjuryAdultAntinematodal AgentsAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisCocaineCreatinineGlomerulonephritisGlomerulosclerosis, Focal SegmentalHematuriaHumansImmunosuppressive AgentsLevamisoleMaleProteinuriaSteroidsTreatment OutcomeAntinematodal AgentsCocaineCreatinineImmunosuppressive AgentsLevamisoleSteroidsacute renal failurechronic renal failuredrug misuse (including addiction)hematuriavasculitis

Identifiers

PMID30232205
PMCPMC6150162
OpenAlexW2891904425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.