Evidence map›Paper›PMID 30232199›Full record

ArticleGenome research2018

Metagenomic analysis with strain-level resolution reveals fine-scale variation in the human pregnancy microbiome.

Daniela S Aliaga Goltsman, Christine L Sun, Diana M Proctor, Daniel B DiGiulio, Anna Robaczewska, Brian C Thomas, Gary M Shaw, David K Stevenson, Susan P Holmes, Jillian F Banfield and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 5 syntheses or guidelines pooled it, 159 citations in OpenAlex.

  1. Pooled it
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  11. Progress in interventions for vaginal microecology.Frontiers in cellular and infection microbiology · 2026
    Review
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  20. Evidence ofMicrobial genomics · 2024
    Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Daniela S Aliaga Goltsman *March of Dimes Prematurity Research Center at Stanford University, Stanford, California 94305, USA.
Christine L Sun *March of Dimes Prematurity Research Center at Stanford University, Stanford, California 94305, USA.
Diana M ProctorDepartment of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.ORCID 0000-0002-7078-0669
Daniel B DiGiulioMarch of Dimes Prematurity Research Center at Stanford University, Stanford, California 94305, USA.
Anna RobaczewskaMarch of Dimes Prematurity Research Center at Stanford University, Stanford, California 94305, USA.
Brian C ThomasDepartment of Earth and Planetary Science, University of California, Berkeley, California 94720, USA.
Gary M ShawMarch of Dimes Prematurity Research Center at Stanford University, Stanford, California 94305, USA.
David K StevensonMarch of Dimes Prematurity Research Center at Stanford University, Stanford, California 94305, USA.
Susan P HolmesDepartment of Statistics, Stanford University, Stanford, California 94305, USA.
Jillian F BanfieldDepartment of Earth and Planetary Science, University of California, Berkeley, California 94720, USA.
David A RelmanMarch of Dimes Prematurity Research Center at Stanford University, Stanford, California 94305, USA.ORCID 0000-0001-8331-1354
March of Dimes · USPlanetary Science Institute · USStanford University · USVA Palo Alto Health Care System · US

Funding

Gene Expression Analyses of the Human Microbiome During Pregnancy through MetatranscriptomicsK99HD090290 · NICHD · STANFORD UNIVERSITY · PI GOLTSMAN, DANIELA · 2017 to 2018
$203k
NICHD NIH HHS K99 HD090290
6 · The paper itself

Abstract

Recent studies suggest that the microbiome has an impact on gestational health and outcome. However, characterization of the pregnancy-associated microbiome has largely relied on 16S rRNA gene amplicon-based surveys. Here, we describe an assembly-driven, metagenomics-based, longitudinal study of the vaginal, gut, and oral microbiomes in 292 samples from 10 subjects sampled every three weeks throughout pregnancy. Nonhuman sequences in the amount of 1.53 Gb were assembled into scaffolds, and functional genes were predicted for gene- and pathway-based analyses. Vaginal assemblies were binned into 97 draft quality genomes. Redundancy analysis (RDA) of microbial community composition at all three body sites revealed gestational age to be a significant source of variation in patterns of gene abundance. In addition, health complications were associated with variation in community functional gene composition in the mouth and gut. The diversity of

Indexed as

BacteriaContig MappingDNA, BacterialDNA, RibosomalFemaleGastrointestinal TractHumansLongitudinal StudiesMetagenomicsPhylogenyPregnancyPregnancy OutcomeRNA, Ribosomal, 16SSequence Analysis, DNAVaginaDNA, BacterialDNA, RibosomalRNA, Ribosomal, 16S

Identifiers

PMID30232199
PMCPMC6169887
OpenAlexW2952492514

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.