Evidence map›Paper›PMID 30232189›Full record

ArticleJournal of virology2018

Sindbis Virus Infection Causes Cell Death by nsP2-Induced Transcriptional Shutoff or by nsP3-Dependent Translational Shutoff.

Ivan Akhrymuk, Ilya Frolov, Elena I Frolova

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Microbiology spectrum · 2026
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  5. Review
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  7. Review
  8. Review
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  12. Article
  13. Mimicking superinfection exclusion disrupts alphavirus infection and transmission in the yellow fever mosquitoProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Molecular Virology of Chikungunya Virus.Current topics in microbiology and immunology · 2022
    Review
  20. Innate immune evasion by alphaviruses.Frontiers in immunology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ivan AkhrymukDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ilya FrolovDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-8548-2517
Elena I FrolovaDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA efrolova@uab.edu.ORCID 0000-0001-6523-9336
University of Alabama at Birmingham · US

Funding

Mechanistic role of ns2 protein in evasion of innate immune response by alphavirusesR01AI133159 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FROLOVA, ELENA I · 2017 to 2021
$3.0M
Alphavirus nsP3 protein: roles of intrinsically disordered region in virus replication and pathogenesisR01AI118867 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FROLOVA, ELENA I · 2015 to 2019
$1.8M
Sindbis nonstructural protein nsP2: Interaction with cellular proteinsR01AI073301 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI FROLOVA, ELENA I · 2008 to 2012
$1.6M
NIAID NIH HHS R01 AI073301NIAID NIH HHS R01 AI118867NIAID NIH HHS R01 AI133159
6 · The paper itself

Abstract

Sindbis virus (SINV) is a representative member of the

Indexed as

Cytopathogenic Effect, ViralProtein BiosynthesisTranscription, GeneticAlphavirus InfectionsAnimalsCysteine EndopeptidasesGenome, ViralMiceNIH 3T3 CellsSindbis VirusViral Nonstructural ProteinsVirionVirus ReplicationCysteine EndopeptidasesnsP2 proteinasensp3 protein, alphavirusViral Nonstructural Proteinsalphaviruseschikungunya virusmacrodomainmoncytopathic replicationmono-ADP-ribosylhydrolasensP2nsP3Sindbis virustranscription inhibitiontranslation inhibition

Identifiers

PMID30232189
PMCPMC6232463
OpenAlexW2890473342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.