Evidence map›Paper›PMID 30232153›Full record

ArticleThe Journal of biological chemistry2018

Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of

Noelia Lander, Miguel A Chiurillo, Mayara S Bertolini, Melissa Storey, Anibal E Vercesi, Roberto Docampo

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 48 citations in OpenAlex.

  1. Article
  2. Mitochondrial Calcium Signaling in Hepatocyte Health and Disease.Cold Spring Harbor perspectives in biology · 2026
    Review
  3. Review
  4. Mitochondrial CaNature metabolism · 2026
    Article
  5. Cloning-Free Genome Editing by CRISPR/T7RNAP/Cas9 in Trypanosoma cruzi.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  6. Article
  7. Mitochondrial CaJournal of cellular physiology · 2025
    Review
  8. Article
  9. Review
  10. Metacyclogenesis as the Starting Point of Chagas Disease.International journal of molecular sciences · 2023
    Review
  11. CRISPR Genome Editing and the Study of Chagas Disease.Advances in experimental medicine and biology · 2023
    Article
  12. Comparative proteomics analysis of adultFrontiers in cellular and infection microbiology · 2023
    Article
  13. Virulence · 2022
    Article
  14. Article
  15. Article
  16. The Kinetoplastid-Specific Protein TcCAL1 Plays Different Roles DuringFrontiers in cellular and infection microbiology · 2022
    Article
  17. Acute RyR1 CaNature communications · 2021
    Article
  18. The long and winding road of reverse genetics inMicrobial cell (Graz, Austria) · 2021
    Article
  19. Trypanosoma cruzi Letm1 is involved in mitochondrial CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Noelia LanderFrom the Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, São Paulo, 13083, Brazil and noelia@uga.edu.
Miguel A ChiurilloFrom the Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, São Paulo, 13083, Brazil and.
Mayara S BertoliniFrom the Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, São Paulo, 13083, Brazil and.
Melissa StoreyCenter for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, 30602.
Anibal E VercesiFrom the Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, São Paulo, 13083, Brazil and.
Roberto DocampoFrom the Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, São Paulo, 13083, Brazil and rdocampo@uga.edu.ORCID 0000-0003-4229-8784
Universidade Estadual de Campinas (UNICAMP) · BRUniversity of Georgia · US

Funding

Pathogenesis of Trypanosoma cruzi infectionR01AI107663 · NIAID · UNIVERSITY OF GEORGIA · PI DOCAMPO, ROBERTO · 2014 to 2017
$1.5M
Pathogenesis of Trypanosoma cruzi infectionR56AI107663 · NIAID · UNIVERSITY OF GEORGIA · PI DOCAMPO, ROBERTO · 2013 to 2013
$350k
NIAID NIH HHS R01 AI107663NIAID NIH HHS R56 AI107663
6 · The paper itself

Abstract

In vertebrate cells, mitochondrial Ca

Indexed as

Energy MetabolismCell LineChagas DiseaseGene Knockdown TechniquesHumansKetone OxidoreductasesPhosphorylationProtozoan ProteinsTrypanosoma cruziKetone OxidoreductasesProtozoan Proteinspyruvate dehydrogenase (NADP+)bioenergeticscalciumcalcium signalingCRISPR/Cas9energy metabolismmitochondrial calcium uniportermitochondrial dehydrogenasepyruvate dehydrogenase phosphataseTrypanosoma cruzi

Identifiers

PMID30232153
PMCPMC6231137
OpenAlexW2891719237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.