Trial reportArchives of disease in childhood. Fetal and neonatal edition2019
Targeting glucose control in preterm infants: pilot studies of continuous glucose monitoring.
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants.The Cochrane database of systematic reviews · 2021Pooled it
- Eligibility Criteria and Representativeness of Randomized Clinical Trials That Include Infants Born Extremely Premature: A Systematic Review.The Journal of pediatrics · 2021Pooled it
- Interventions to minimize blood loss in very preterm infants-A systematic review and meta-analysis.PloS one · 2021Pooled it
- Accuracy of continuous glucose monitoring in preterm infants: a systematic review and meta-analysis.BMJ open · 2020Pooled it
- Continuous glucose monitoring for the prevention of morbidity and mortality in preterm infants.The Cochrane database of systematic reviews · 2020Pooled it
- Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial.The Lancet. Child & adolescent health · 2021Trial
- Feasibility of automated insulin delivery guided by continuous glucose monitoring in preterm infants.Archives of disease in childhood. Fetal and neonatal edition · 2020Trial
- Current Practices in Hyperglycemia Management in Neonatal Encephalopathy: A Treatment of Hyperglycemia in Neonatal Encephalopathy (THiNE) Consortium Study.American journal of perinatology · 2026Article
- The neonatal continuous glucose monitoring paradox: why at-risk infants still lack access to a transformative technology-A call for needs-led innovation.Frontiers in medicine · 2026Article
- Glucose disturbances in very low birth weight infants nearing term age-results from the prospective LIGHT-study using continuous glucose monitoring.European journal of pediatrics · 2025Observational
- Agreement between intermittent glucose concentrations and continuous glucose monitoring in at-risk newborns.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Hyperglycemia and prematurity: a narrative review.Pediatric research · 2023Review
- Dilemmas in parenteral glucose delivery and approach to glucose monitoring and interpretation in the neonate.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Should continuous glucose monitoring be used to manage neonates at risk of hypoglycaemia?Frontiers in pediatrics · 2023Review
- Continuous Glucose Monitoring in Preterm Infants: The Role of Nutritional Management in Minimizing Glycemic Variability.Antioxidants (Basel, Switzerland) · 2022Article
- Continuous Glucose Monitoring in the Management of Neonates With Persistent Hypoglycemia and Congenital Hyperinsulinism.The Journal of clinical endocrinology and metabolism · 2022Article
- Safety and feasibility of a factory-calibrated continuous glucose monitoring system in term and near-term infants at risk of hypoglycemia.Turkish archives of pediatrics · 2021Article
- Hyperglycaemia in the Newborn Infant. Physiology Verses Pathology.Frontiers in pediatrics · 2021Review
- Care opportunities for premature infants: home visits and telephone support.Revista latino-americana de enfermagem · 2020Article
- Continuous glucose monitoring in the neonatal intensive care unit: not quite ready for 'plug and play'.Archives of disease in childhood. Fetal and neonatal edition · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveHyperglycaemia is common in very preterm infants and is associated with adverse outcomes. Preventing hyperglycaemia without increasing the risk of hypoglycaemia is difficult. Real time tracking with continuous glucose monitors (CGM) may improve glucose control. We assessed the feasibility and safety of CGM to target glucose control in preterm infants, to inform a randomised controlled trial (RCT).
designWe performed a single centre study in very preterm infants during the first week of life. Accuracy was assessed by comparison of CGM with blood glucose levels (n=20 infants). In a separate pilot study of efficacy (n=20), real-time CGM combined with a paper guideline to target glucose control (2.6-10 mmol/L) was compared with standard neonatal care (masked CGM). Questionnaires were used to assess staff acceptability.
resultsNo concerns were raised about infection or skin integrity at sensor site. The sensor performed well compared with point-of-care blood glucose measurements, mean bias of -0.27 (95% CI -0.35 to -0.19). Per cent time in target range (sensor glucose 2.6-10 mmol/L) was greater with CGM than POC (77% vs 59%, respectively) and per cent time sensor glucose >10 mmol/L was less with CGM than POC (24% vs 40%, respectively). The CGM also detected clinically unsuspected episodes of hypoglycaemia. Staff reported that the use of the CGM positively improved clinical care.
conclusionsThis study suggests that CGM has sufficient accuracy and utility in preterm infants to warrant formal testing in a RCT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.