ArticleCell reports2018
Sugar Promotes Feeding in Flies via the Serine Protease Homolog scarface.
Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 16 citations in OpenAlex.
- Host selection in Megabruchidius dorsalis under storage conditions: investigating the role of visual, gustatory and olfactory cues in feeding and reproductive behaviors.Pest management science · 2026Article
- In the battle of the disease: a transcriptomic analysis of European foulbrood-diseased larvae of the Western honey bee (Apis mellifera).BMC genomics · 2022Article
- Induction and inhibition of Drosophila X chromosome gene expression are both impeded by the dosage compensation complex.G3 (Bethesda, Md.) · 2022Article
- The Serine Protease Homolog, Scarface, Is Sensitive to Nutrient Availability and Modulates the Development of theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Diet-MEF2 interactions shape lipid droplet diversification in muscle to influence Drosophila lifespan.Aging cell · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A balanced diet of macronutrients is critical for animal health. A lack of specific elements can have profound effects on behavior, reproduction, and lifespan. Here, we used Drosophila to understand how the brain responds to carbohydrate deprivation. We found that serine protease homologs (SPHs) are enriched among genes that are transcriptionally regulated in flies deprived of carbohydrates. Stimulation of neurons expressing one of these SPHs, Scarface (Scaf), or overexpression of scaf positively regulates feeding on nutritious sugars, whereas inhibition of these neurons or knockdown of scaf reduces feeding. This modulation of food intake occurs only in sated flies while hunger-induced feeding is unaffected. Furthermore, scaf expression correlates with the presence of sugar in the food. As Scaf and Scaf neurons promote feeding independent of the hunger state, and the levels of scaf are positively regulated by the presence of sugar, we conclude that scaf mediates the hedonic control of feeding.
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Registered trials
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