ArticleBiological research2018
Thiamine deficiency contributes to synapse and neural circuit defects.
Article in Biological research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Unraveling the nutritional challenges in epilepsy: Risks, deficiencies, and management strategies: A systematic review.World journal of experimental medicine · 2025Article
- Lower water-soluble vitamins and higher homocysteine are associated with neurodegenerative diseases.Scientific reports · 2025Article
- Thiamine and Thiamine Pyrophosphate as Non-Competitive Inhibitors of Acetylcholinesterase-Experimental and Theoretical Investigations.Molecules (Basel, Switzerland) · 2025Article
- Integrated Bulk and Single-Cell RNA-Sequencing Reveals the Effects of Circadian Rhythm Disruption on the Metabolic Reprogramming of CD4+ T Cells in Alzheimer's Disease.Molecular neurobiology · 2024Article
- Review
- The importance of thiamine (vitamin B1) in humans.Bioscience reports · 2023Article
- Revisiting the Role of Vitamins and Minerals in Alzheimer's Disease.Antioxidants (Basel, Switzerland) · 2023Review
- Seeing Neurodegeneration in a New Light Using Genetically Encoded Fluorescent Biosensors and iPSCs.International journal of molecular sciences · 2023Review
- Metabolic Features of Brain Function with Relevance to Clinical Features of Alzheimer and Parkinson Diseases.Molecules (Basel, Switzerland) · 2022Review
- Thiamine Deficiency Increases Intrinsic Excitability of Mouse Cerebellar Purkinje Cells.Cerebellum (London, England) · 2021Article
- Sex Differences in the Relationship of Serum Vitamin B1 and B12 to Dementia Among Memory Clinic Outpatients in Japan.Frontiers in aging neuroscience · 2021Article
- Supplemental thiamine as a practical, potential way to prevent Alzheimer's disease from commencing.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Metabolic Dysregulation Contributes to the Progression of Alzheimer's Disease.Frontiers in neuroscience · 2020Review
- Thiamine deficiency affects glucose transport and β-oxidation in rats.Journal of animal physiology and animal nutrition · 2019Article
- Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe previous studies have demonstrated the reduction of thiamine diphosphate is specific to Alzheimer's disease (AD) and causal factor of brain glucose hypometabolism, which is considered as a neurodegenerative index of AD and closely correlates with the degree of cognitive impairment. The reduction of thiamine diphosphate may contribute to the dysfunction of synapses and neural circuits, finally leading to cognitive decline.
resultsTo demonstrate this hypothesis, we established abnormalities in the glucose metabolism utilizing thiamine deficiency in vitro and in vivo, and we found dramatically reduced dendrite spine density. We further detected lowered excitatory neurotransmission and impaired hippocampal long-term potentiation, which are induced by TPK RNAi in vitro. Importantly, via treatment with benfotiamine, Aβ induced spines density decrease was considerably ameliorated.
conclusionsThese results revealed that thiamine deficiency contributed to synaptic dysfunction which strongly related to AD pathogenesis. Our results provide new insights into pathogenesis of synaptic and neuronal dysfunction in AD.
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Registered trials
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