ArticleBMC genomics2018
Comparative genomics of molybdenum utilization in prokaryotes and eukaryotes.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Biological use of molybdenum and tungsten stems back to 3.4 billion years ago.Nature communications · 2026Article
- Lowering the Mo limit for nitrogen fixation by Mo-nitrogenase.Communications earth & environment · 2026Article
- Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA.Communications biology · 2025Article
- Article
- Alternative sources of molybdenum for Methanococcus maripaludis and their implication for the evolution of molybdoenzymes.Communications biology · 2024Article
- Impact of mineral and non-mineral sources of iron and sulfur on the metalloproteome ofApplied and environmental microbiology · 2024Article
- Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA.bioRxiv : the preprint server for biology · 2024Article
- Fluorescent Protein-Based Sensors for Detecting Essential Metal Ions across the Tree of Life.ACS sensors · 2024Review
- [Construction and characterization of aNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- An organic O donor for biological hydroxylation reactions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Analysis of microbial community evolution, autolysis phenomena, and energy metabolism pathways inFrontiers in microbiology · 2024Article
- Elemental profiling and genome-wide association studies reveal genomic variants modulating ionomic composition inFrontiers in plant science · 2024Article
- Comparative analysis of functional diversity of rumen microbiome in bison and beef heifers.Applied and environmental microbiology · 2023Article
- A step into the rare biosphere: genomic features of the new genusFrontiers in microbiology · 2023Article
- Carbon substrate re-orders relative growth of a bacterium using Mo-, V-, or Fe-nitrogenase for nitrogen fixation.Environmental microbiology · 2022Article
- Biogeographic and Evolutionary Patterns of Trace Element Utilization in Marine Microbial World.Genomics, proteomics & bioinformatics · 2021Article
- Element accumulation performance of living and dead lichens in a large-scale transplant application.Environmental science and pollution research international · 2021Article
- Depletion of Boric Acid and Cobalt from Cultivation Media: Impact on Recombinant Protein Production withBioengineering (Basel, Switzerland) · 2020Article
- Bioinformatics of Metalloproteins and Metalloproteomes.Molecules (Basel, Switzerland) · 2020Review
- Genome-Scale Metabolic Networks Shed Light on the Carotenoid Biosynthesis Pathway in the Brown AlgaeAntioxidants (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMolybdenum (Mo) is an essential micronutrient for almost all biological systems, which holds key positions in several enzymes involved in carbon, nitrogen and sulfur metabolism. In general, this transition metal needs to be coordinated to a unique pterin, thus forming a prosthetic group named molybdenum cofactor (Moco) at the catalytic sites of molybdoenzymes. The biochemical functions of many molybdoenzymes have been characterized; however, comprehensive analyses of the evolution of Mo metabolism and molybdoproteomes are quite limited.
resultsIn this study, we analyzed almost 5900 sequenced organisms to examine the occurrence of the Mo utilization trait at the levels of Mo transport system, Moco biosynthetic pathway and molybdoproteins in all three domains of life. A global map of Moco biosynthesis and molybdoproteins has been generated, which shows the most detailed understanding of Mo utilization in prokaryotes and eukaryotes so far. Our results revealed that most prokaryotes and all higher eukaryotes utilize Mo whereas many unicellular eukaryotes such as parasites and most yeasts lost the ability to use this metal. By characterizing the molybdoproteomes of all organisms, we found many new molybdoprotein-rich species, especially in bacteria. A variety of new domain fusions were detected for different molybdoprotein families, suggesting the presence of novel proteins that are functionally linked to molybdoproteins or Moco biosynthesis. Moreover, horizontal gene transfer event involving both the Moco biosynthetic pathway and molybdoproteins was identified. Finally, analysis of the relationship between environmental factors and Mo utilization showed new evolutionary trends of the Mo utilization trait.
conclusionsOur data provide new insights into the evolutionary history of Mo utilization in nature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.