Evidence map›Paper›PMID 30231573›Full record

ArticlePharmacy (Basel, Switzerland)2018

Adverse Drug Reactions, Power, Harm Reduction, Regulation and the ADRe Profiles.

Sue Jordan, Patricia A Logan, Gerwyn Panes, Mojtaba Vaismoradi, David Hughes

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacy (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03955133 (Polypharmacy and Adverse Drug Reactions), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03955133 nacompletednot on this map

Polypharmacy and Adverse Drug Reactions: Nurse-led Intervention to Minimise Adverse Drug Reactions for Older Adults in Care Homes: a Quality Improvement Process Intervention

TypeinterventionalSponsorSwansea UniversityRan2018 to 2020Enrolled19ConditionsPolypharmacyArmsAdverse Drug Reaction ADRe Profile for Polypharmacy
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. PRN Medicines Optimization and Nurse Education.Pharmacy (Basel, Switzerland) · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Adverse Drug Reactions in Norway: A Systematic Review.Pharmacy (Basel, Switzerland) · 2019
    Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Sue JordanCollege of Human and Health Sciences, Swansea University, Swansea SA2 8PP, UK. s.e.jordan@swansea.ac.uk.
Patricia A LoganFaculty of Science, Charles Sturt University, Bathurst Campus, NSW 2795, Australia. plogan@csu.edu.au.ORCID 0000-0002-7073-3803
Gerwyn PanesCollege of Human and Health Sciences, Swansea University, Swansea SA2 8PP, UK. g.panes@swansea.ac.uk.
Mojtaba VaismoradiFaculty of Nursing and Health Sciences, Nord University, 8049 Bodø, Norway. mojtaba.vaismoradi@nord.no.ORCID 0000-0002-5157-4886
David HughesCollege of Human and Health Sciences, Swansea University, Swansea SA2 8PP, UK. d.hughes@swansea.ac.uk.
Swansea University · GBCharles Sturt University · AUNord University · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The power and influence of healthcare systems comes largely from the ability to prescribe efficacious medicine. However, medicine can sometimes cause harm rather than bring benefits. Systematically checking patients for the adverse effects of medicines, as listed in manufacturers' literature, would protect patients from iatrogenic harm, but this is rarely undertaken. We argue for the benefits of this approach using the example of the prescription of antipsychotics to older adults. Prescribing antipsychotics to control challenging behaviours associated with dementia is a controversial matter, and regulatory intervention is under discussion. Improved regulatory systems could protect against iatrogenic harm, such as over-sedation, falls, tremor, or drug-induced Parkinsonism. However, measuring the impact and outcomes of regulatory interventions has proved difficult, not least because there are rarely systematic records of all adverse effects of medicines. We indicate how regulatory initiatives to reduce antipsychotic prescribing can be supported by systematic monitoring and documentation of patients' signs and symptoms of putative adverse drug reactions. Monitoring documentation then provides the rationale and support for professionals' responses to identified problems. Longitudinal monitoring records would improve understanding of the impact and outcomes of adverse drug reactions (ADRs) on health and wellbeing, and the many costs of ADRs.

Indexed as

adverse drug reactionslong-term caremedicine managementnursingpatient safety

Identifiers

PMID30231573
PMCPMC6165166
OpenAlexW2891456814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.