Evidence map›Paper›PMID 30231570›Full record

ArticleToxins2018

Soluble Toll-Like Receptor 4 Impairs the Interaction of Shiga Toxin 2a with Human Serum Amyloid P Component.

Maurizio Brigotti, Valentina Arfilli, Domenica Carnicelli, Francesca Ricci, Pier Luigi Tazzari, Gianluigi Ardissino, Gaia Scavia, Stefano Morabito, Xiaohua He

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. EnterohemorrhagicInternational journal of molecular sciences · 2022
    Review
  3. Toll-Like Receptors in Acute Kidney Injury.International journal of molecular sciences · 2021
    Review
  4. Review
  5. Molecular Biology ofToxins · 2020
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Maurizio BrigottiDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. maurizio.brigotti@unibo.it.
Valentina ArfilliDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. arfilli.f@libero.it.
Domenica CarnicelliDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via San Giacomo 14, 40126 Bologna, Italy. domenica.carnicelli@unibo.it.ORCID 0000-0001-6502-7042
Francesca RicciImmunohematology and Transfusion Center, S. Orsola-Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy. francesca.ricci@aosp.bo.it.ORCID 0000-0003-4387-1415
Pier Luigi TazzariImmunohematology and Transfusion Center, S. Orsola-Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy. pierluigi.tazzari@aosp.bo.it.
Gianluigi ArdissinoCenter for HUS Control, Prevention and Management, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Via Commenda 9, 20122 Milano, Italy. ardissino@italkid.org.
Gaia ScaviaEuropean Reference Laboratory for Escherichia coli, Istituto Superiore di Sanità, 00161 Rome, Italy. gaia.scavia@iss.it.
Stefano MorabitoEuropean Reference Laboratory for Escherichia coli, Istituto Superiore di Sanità, 00161 Rome, Italy. stefano.morabito@iss.it.
Xiaohua HeWestern Regional Research Center, U.S. Department of Agriculture, Agricultural Research Service, 800 Buchanan Street, Albany, CA 94710, USA. xiaohua.he@ars.usda.gov.
University of Bologna · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITIstituto Superiore di Sanità · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITWestern Regional Research Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shiga toxin 2a (Stx2a) is the main virulence factor produced by pathogenic

Indexed as

Cell Line, TumorHumansNeutrophilsProtein DomainsSerum Amyloid P-ComponentShiga Toxin 2Toll-Like Receptor 4Serum Amyloid P-ComponentShiga Toxin 2TLR4 protein, humanToll-Like Receptor 4decoy receptorshemolytic uremic syndromeHuSAPShiga toxinsToll-like receptor 4

Identifiers

PMID30231570
PMCPMC6162853
OpenAlexW2891709595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.