Evidence map›Paper›PMID 30231548›Full record

ArticleJournal of cardiovascular development and disease2018

Analysis of Angiotensin Converting Enzyme, Endothelial Nitric Oxide Synthase & Serotonin Gene Polymorphisms among Atrial Septal Defect Subjects with and without Pulmonary Arterial Hypertension.

Nur Ilyana Jaafar, Ramachandran Vasudevan, Patimah Ismail, Ahmad Fazli Abdul Aziz, Nur Afiqah Mohamad, Geetha Kandavello, Raja Nurzatul Effah Raja Adnan, Vinod Balasubramaniam

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular development and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. The Impact ofIn vivo (Athens, Greece)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nur Ilyana JaafarDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia. elle.ilyana@gmail.com.
Ramachandran VasudevanMalaysian Research Institute on Ageing, Universiti Putra Malaysia, Serdang 43400, Malaysia. vasuphd@gmail.com.
Patimah IsmailDepartment of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia. patimah@upm.edu.my.
Ahmad Fazli Abdul AzizDepartment of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia. afazli@upm.edu.my.
Nur Afiqah MohamadMalaysian Research Institute on Ageing, Universiti Putra Malaysia, Serdang 43400, Malaysia. nur_iqa87@yahoo.com.ORCID 0000-0002-9015-0525
Geetha KandavelloDepartment of Pediatric Clinic, National Heart Institute, Jalan Tun Razak, Kuala Lumpur 50400, Malaysia. geetha@ijn.com.my.
Raja Nurzatul Effah Raja AdnanMalaysian Research Institute on Ageing, Universiti Putra Malaysia, Serdang 43400, Malaysia. r_zatulefa@upm.edu.my.
Vinod BalasubramaniamJeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Malaysia. vinod.balasubramaniam@monash.edu.
Universiti Putra Malaysia · MYMonash University Malaysia · MYNational Heart Institute · MY

Funding

Universiti Putra Malaysia 911440
6 · The paper itself

Abstract

Genetic polymorphisms are variations in DNA sequences which can influence either disease susceptibility, severity, or prognosis. Pulmonary arterial hypertension (PAH) is one of the complications that occurs in certain patients who have atrial septal defect (ASD). This study seeks to determine the association of gene polymorphisms with the pathogenesis of PAH in ASD patients. This study was conducted on 30 ASD patients with PAH, and 50 ASD patients who were not diagnosed with PAH. All respondents were Malay. Patients were selected based on stringent inclusion and exclusion criteria. Molecular analyses were done to detect the genetic polymorphisms of angiotensin converting enzyme (

Indexed as

atrial septal defectgenetic polymorphismspulmonary artery hypertension

Identifiers

PMID30231548
PMCPMC6162525
OpenAlexW2889810603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.