Evidence map›Paper›PMID 30231499›Full record

ReviewMolecules (Basel, Switzerland)2018

Deep Learning in Drug Discovery and Medicine; Scratching the Surface.

Dibyendu Dana, Satishkumar V Gadhiya, Luce G St Surin, David Li, Farha Naaz, Quaisar Ali, Latha Paka, Michael A Yamin, Mahesh Narayan, Itzhak D Goldberg and 1 more

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review on Advancement of AI in Cell Engineering and Molecular Biology.Methods in molecular biology (Clifton, N.J.) · 2025
    Review
  7. Article
  8. Review
  9. Improved Prediction of Ligand-Protein Binding Affinities by Meta-modeling.Journal of chemical information and modeling · 2024
    Article
  10. Advances in artificial intelligence-based technologies for increasing the quality of medical products.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
    Review
  11. Artificial intelligence as a tool in drug discovery and development.World journal of experimental medicine · 2024
    Review
  12. Review
  13. Review
  14. Review
  15. Prediction of COVID-19 Patients' Emergency Room Revisit using Multi-Source Transfer Learning.Proceedings. IEEE International Conference on Healthcare Informatics · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Machine Learning and Deep Learning for the Pharmacogenomics of Antidepressant Treatments.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dibyendu DanaDepartment of Preclinical Research, Angion Biomedica Corporation, Nassau, NY 11553, USA. ddana@angion.com.
Satishkumar V GadhiyaDepartment of Preclinical Research, Angion Biomedica Corporation, Nassau, NY 11553, USA. sgadhiya@angion.com.
Luce G St SurinDepartment of Preclinical Research, Angion Biomedica Corporation, Nassau, NY 11553, USA. lstsuri1@jhu.edu.
David LiDepartment of Preclinical Research, Angion Biomedica Corporation, Nassau, NY 11553, USA. david_li@college.harvard.edu.
Farha NaazDepartment of Preclinical Research, Angion Biomedica Corporation, Nassau, NY 11553, USA. fnaaz@angion.com.
Quaisar AliDepartment of Preclinical Research, Angion Biomedica Corporation, Nassau, NY 11553, USA. qali@angion.com.
Latha PakaDepartment of Preclinical Research, Angion Biomedica Corporation, Nassau, NY 11553, USA. spaka@angion.com.
Michael A YaminDepartment of Preclinical Research, Angion Biomedica Corporation, Nassau, NY 11553, USA. myamin@angion.com.
Mahesh NarayanDepartment of Chemistry and Biochemistry, The University of Texas, El Paso, TX 79968, USA. manarayan@utep.edu.
Itzhak D GoldbergDepartment of Preclinical Research, Angion Biomedica Corporation, Nassau, NY 11553, USA. igoldberg@angion.com.
Prakash NarayanDepartment of Preclinical Research, Angion Biomedica Corporation, Nassau, NY 11553, USA. pnarayan@angion.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The practice of medicine is ever evolving. Diagnosing disease, which is often the first step in a cure, has seen a sea change from the discerning hands of the neighborhood physician to the use of sophisticated machines to use of information gleaned from biomarkers obtained by the most minimally invasive of means. The last 100 or so years have borne witness to the enormous success story of allopathy, a practice that found favor over earlier practices of medical purgatory and homeopathy. Nevertheless, failures of this approach coupled with the omics and bioinformatics revolution spurred precision medicine, a platform wherein the molecular profile of an individual patient drives the selection of therapy. Indeed, precision medicine-based therapies that first found their place in oncology are rapidly finding uses in autoimmune, renal and other diseases. More recently a new renaissance that is shaping everyday life is making its way into healthcare. Drug discovery and medicine that started with Ayurveda in India are now benefiting from an altogether different artificial intelligence (AI)-one which is automating the invention of new chemical entities and the mining of large databases in health-privacy-protected vaults. Indeed, disciplines as diverse as language, neurophysiology, chemistry, toxicology, biostatistics, medicine and computing have come together to harness algorithms based on transfer learning and recurrent neural networks to design novel drug candidates, a priori inform on their safety, metabolism and clearance, and engineer their delivery but only on demand, all the while cataloging and comparing omics signatures across traditionally classified diseases to enable basket treatment strategies. This review highlights inroads made and being made in directed-drug design and molecular therapy.

Indexed as

Deep LearningDrug DiscoveryPrecision MedicineArtificial IntelligenceDrug DesignDrug RepositioningNeural Networks, ComputerPoint-of-Care Systemsartificial intelligencedeep learningde novo designdrug discoveryprecision medicinerecurrent neural networkssmall moleculestherapeuticstransfer learning

Identifiers

PMID30231499
PMCPMC6225282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.