Evidence map›Paper›PMID 30231297›Full record

ArticleClinical and experimental immunology2018

High MDR-1 expression by MAIT cells confers resistance to cytotoxic but not immunosuppressive MDR-1 substrates.

J R Fergusson, J E Ussher, A Kurioka, P Klenerman, L J Walker

Open access · hybridAbstract read
In one paragraph

Article in Clinical and experimental immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. [Curcumin-loaded nanoparticles reversed radiotherapy-triggered enhancement of MDR1 expression of CNE-2 cells in nasopharyngeal carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. MAIT Cells Modulate Innate Immune Cells and Inhibit Colon Cancer Growth.bioRxiv : the preprint server for biology · 2024
    Article
  9. Article
  10. Review
  11. Review
  12. Involvement of impaired CD8Reproductive biology and endocrinology : RB&E · 2021
    Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Mucosal-Associated Invariant T cell in liver diseases.International journal of biological sciences · 2020
    Review
  18. Article
  19. CD4Reproductive biology and endocrinology : RB&E · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

J R FergussonPeter Medawar Building for Pathogen Research, Oxford, UK.
J E UssherPeter Medawar Building for Pathogen Research, Oxford, UK.
A KuriokaPeter Medawar Building for Pathogen Research, Oxford, UK.
P KlenermanPeter Medawar Building for Pathogen Research, Oxford, UK.
L J WalkerInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne.
Medawar Building for Pathogen Research · GBNewcastle University · GBUniversity of Otago · NZ

Funding

Medical Research CouncilWellcome Trust 092871/Z/10/ZWellcome Trust 109965/Z/15/ZWellcome Trust WT091663MA
6 · The paper itself

Abstract

High expression of the ATP-binding cassette-multi-drug efflux protein 1 (MDR1) is a striking feature of mucosal-associated invariant T (MAIT) cells, a prominent human innate-like T cell subset. We demonstrate significantly higher MDR1 expression by CD8

Indexed as

Antibiotics, AntineoplasticApoptosisATP Binding Cassette Transporter, Subfamily B, Member 1CD8 AntigensCD8-Positive T-LymphocytesCell ProliferationCytotoxicity, ImmunologicDaunorubicinDrug ResistanceHumansImmunity, MucosalImmunosuppressive AgentsMucosal-Associated Invariant T CellsMycophenolic AcidNK Cell Lectin-Like Receptor Subfamily BReceptors, Antigen, T-Cell, alpha-betaAntibiotics, AntineoplasticATP Binding Cassette Transporter, Subfamily B, Member 1CD8 AntigensDaunorubicinImmunosuppressive AgentsMycophenolic AcidNK Cell Lectin-Like Receptor Subfamily BReceptors, Antigen, T-Cell, alpha-betaTacrolimusautoimmunitymalignancyMDR1mucosal-associated invariant T (MAIT) celltransplant

Identifiers

PMID30231297
PMCPMC6194332
OpenAlexW2892165822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.