ArticleBiochemistry2018
Crystal Structures of Candida albicans Phosphodiesterase 2 and Implications for Its Biological Functions.
Ting Yao, Yiyou Huang, Meng Zhang, Yujuan Chen, Hairun Pei, Jianyou Shi, Huanchen Wang, Yousheng Wang, Hengming Ke
Open access · greenAbstract read
In one paragraphArticle in Biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 92% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors at 3 institutions in 2 countries.
Ting YaoBeijing Advanced Innovation Center for Food Nutrition and Human Health , Beijing Technology and Business University , Beijing 100048 , China.
Yiyou HuangDepartment of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center , The University of North Carolina , Chapel Hill , North Carolina 27599-7260 , United States.
Meng ZhangBeijing Advanced Innovation Center for Food Nutrition and Human Health , Beijing Technology and Business University , Beijing 100048 , China.
Yujuan ChenBeijing Advanced Innovation Center for Food Nutrition and Human Health , Beijing Technology and Business University , Beijing 100048 , China.
Hairun PeiBeijing Advanced Innovation Center for Food Nutrition and Human Health , Beijing Technology and Business University , Beijing 100048 , China.
Jianyou ShiDepartment of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center , The University of North Carolina , Chapel Hill , North Carolina 27599-7260 , United States.
Huanchen WangLaboratory of Signal Transduction, National Institute of Environmental Health Sciences , National Institutes of Health , 111 Alexander Drive , Research Triangle Park , North Carolina 27709 , United States.
Yousheng WangBeijing Advanced Innovation Center for Food Nutrition and Human Health , Beijing Technology and Business University , Beijing 100048 , China.
Hengming KeDepartment of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center , The University of North Carolina , Chapel Hill , North Carolina 27599-7260 , United States.ORCID 0000-0001-8864-7279 Beijing Technology and Business University · CNUniversity of North Carolina at Chapel Hill · USNational Institutes of Health · US
Funding
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5MInositol SignallingZIAES080046 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SHEARS, STEPHEN B · 2009 to 2023
$31.3MREGULATION OF INOSITOL LIPID SIGNALLING MECHANISMSZ01ES080046 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SHEARS, STEPHEN B · 1990 to 2008
$4.3MSubstrate specificity and inhibitor selectivity of PDER01GM059791 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KE, HENGMING · 2000 to 2013
$3.0MIntramural NIH HHS Z01 ES080046Intramural NIH HHS ZIA ES080046NCI NIH HHS P30 CA016086NIGMS NIH HHS R01 GM059791
6 · The paper itselfAbstract
The cAMP signaling system plays important roles in the physiological processes of pathogen yeast Candida albicans, but its functional mechanism has not been well illustrated. Here, we report the enzymatic characterization and crystal structures of C. albicans phosphodiesterase 2 (caPDE2) in the unliganded and 3-isobutyl-1-methylxanthine-complexed forms. caPDE2 is a monomer in liquid and crystal states and specifically hydrolyzes cAMP with a K
Indexed as
Candida albicansCrystallography, X-RayCyclic Nucleotide Phosphodiesterases, Type 2Fungal ProteinsProtein DomainsProtein Structure, SecondaryStructure-Activity RelationshipCyclic Nucleotide Phosphodiesterases, Type 2Fungal Proteins
Identifiers
PMID30231198
PMCPMC9364965
OpenAlexW2890690413
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390