Evidence map›Paper›PMID 30231052›Full record

SynthesisPloS one2018

The efficacy and safety of dexmedetomidine in cardiac surgery patients: A systematic review and meta-analysis.

Guobin Wang, Jianhua Niu, Zhitao Li, Haifeng Lv, Hongliu Cai

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 8 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 8 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
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  3. DEX, Delirium and Dilemma.Brazilian journal of cardiovascular surgery · 2023
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  12. Fast-Track Extubation After Cardiac Surgery: A Narrative Review.Journal of cardiovascular development and disease · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Guobin WangDepartment of Surgical Intensive Care Unit, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, Zhejiang, P.R. China.ORCID 0000-0002-4824-3904
Jianhua NiuDepartment of Surgical Intensive Care Unit, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, Zhejiang, P.R. China.
Zhitao LiDepartment of Surgical Intensive Care Unit, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, Zhejiang, P.R. China.ORCID 0000-0003-2629-6404
Haifeng LvDepartment of Surgical Intensive Care Unit, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, Zhejiang, P.R. China.
Hongliu CaiDepartment of Surgical Intensive Care Unit, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, Zhejiang, P.R. China.ORCID 0000-0003-3783-8328
Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the efficacy and safety of dexmedetomidine versus any other treatment without dexmedetomidine in patients who have undergone cardiac surgery. Electronic databases including PubMed, Embase, and Cochrane Library were systematically searched without limitations of language and publication time. Randomized controlled trials (RCTs) aiming to evaluate the efficacy and safety of dexmedetomidine versus any other treatment without dexmedetomidine in patients that have undergone cardiac surgery were selected. Endpoints such as hemodynamic indexes and adverse events in eligible studies were extracted by two researchers, independently. The data was analyzed using RevMan 5.3 and Stata 11.0 software. A total of 18 RCTs met the inclusion criteria, involving 1730 patients. Compared to control (any treatment without dexmedetomidine), dexmedetomidine showed a pooled mean difference (MD) of -14.46 [95% confidence interval(CI): -24.69, -4.23; p<0.01] for systolic arterial pressure, a standardized mean difference (SMD) of -1.74 for mean arterial blood pressure (95% CI: -2.80, -0.68; P < 0.01), -2.12 (95%CI: -3.23, -1.00; p<0.01) for heart rate, and combined odds ratio (OR) of 0.22 (95%CI: 0.11, 0.44; p<0.01) for tachycardia, 3.44 (95%CI: 1.95, 5.96; p<0.01) for bradycardia, 0.74 (95%CI: 0.49, 1.12; p>0.05) for atrial fibrillation, and 0.99 (95%CI: 0.51, 1.90; p>0.05) for hypotension. In addition, dexmedetomidine could reduce time of surgery and stay in intensive care units, improve delirium with good safety. Our study shows clinical application of dexmedetomidine in cardiac surgery patients can reduce risks of abnormal hemodynamics with good safety.

Indexed as

Analgesics, Non-NarcoticCardiac Surgical ProceduresDexmedetomidineHemodynamicsHumansIntensive Care UnitsOperative TimePostoperative ComplicationsRandomized Controlled Trials as TopicAnalgesics, Non-NarcoticDexmedetomidine

Identifiers

PMID30231052
PMCPMC6145508
OpenAlexW2890781023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.