Evidence map›Paper›PMID 30230927›Full record

ReviewAnnual review of genetics2018

Chemical Modifications in the Life of an mRNA Transcript.

Sigrid Nachtergaele, Chuan He

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 135 papers.

0numbers the graph read from it
0cells of the map it votes in
135citing papers in PubMed
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

135 citing papers in PubMed, 239 citations in OpenAlex.

  1. Article
  2. Review
  3. Methylation marks breast cancer metastasis: The roles of mThe Journal of biological chemistry · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Comprehensive analysis and validation of mBMC veterinary research · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Genome-wide profiling of RNA 2'-bioRxiv : the preprint server for biology · 2025
    Article
  16. Article
  17. Article
  18. Identification of the Role ofVeterinary sciences · 2025
    Article
  19. Genetic variants reshape the mScientific reports · 2025
    Article
  20. Article

75 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sigrid NachtergaeleDepartment of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, and Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA; email: shnachte@uchicago.edu , chuanhe@uchicago.edu.
Chuan HeDepartment of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, and Howard Hughes Medical Institute, University of Chicago, Chicago, Illinois 60637, USA; email: shnachte@uchicago.edu , chuanhe@uchicago.edu.
Howard Hughes Medical Institute · USUniversity of Chicago · US

Funding

Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4M
The Stanford Training Program in ELSI ResearchT32HG008953 · NHGRI · STANFORD UNIVERSITY · PI Mildred K. Cho, Meghan Halley · 2016 to 2026
$3.1M
Howard Hughes Medical Institute DRG-2215-15NHGRI NIH HHS RM1 HG008935NHGRI NIH HHS T32 HG008953
6 · The paper itself

Abstract

Investigations over the past eight years of chemical modifications on messenger RNA (mRNA) have revealed a new level of posttranscriptional gene regulation in eukaryotes. Rapid progress in our understanding of these modifications, particularly, N

Indexed as

Protein BiosynthesisAdenosineGene Expression RegulationHumansMethylationRNA, MessengerRNA Processing, Post-TranscriptionalTranscriptomeAdenosineN-methyladenosineRNA, MessengerepitranscriptomeN6-methyladenosineribonucleotide modificationsRNA metabolism

Identifiers

PMID30230927
PMCPMC6436393
OpenAlexW2890330353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.