Evidence map›Paper›PMID 30230700›Full record

ArticleAutism research : official journal of the International Society for Autism Research2018

Behavioral predictors of improved speech output in minimally verbal children with autism.

Karen Chenausky, Andrea Norton, Helen Tager-Flusberg, Gottfried Schlaug

Open access · greenAbstract read
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Proportion and Profile of Autistic Children Not Acquiring Spoken Language Despite Receiving Evidence-Based Early Interventions.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2025
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  9. Speech Development Across Subgroups of Autistic Children: A Longitudinal Study.Journal of autism and developmental disorders · 2023
    Article
  10. Article
  11. Oromotor skills in autism spectrum disorder: A scoping review.Autism research : official journal of the International Society for Autism Research · 2023
    Article
  12. Predictors of individual differences in minimally verbal peer communication exchanges following peer-oriented social intervention.Autism research : official journal of the International Society for Autism Research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Karen ChenauskyMusic, Neuroimaging, and Stroke Recovery Laboratory, Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0000-0002-4294-9228
Andrea NortonMusic, Neuroimaging, and Stroke Recovery Laboratory, Beth Israel Deaconess Medical Center, Boston, MA.
Helen Tager-FlusbergCenter for Autism Research Excellence, Department of Psychological and Brain Sciences, Boston University, Boston, MA.
Gottfried SchlaugMusic, Neuroimaging, and Stroke Recovery Laboratory, Beth Israel Deaconess Medical Center, Boston, MA.
Beth Israel Deaconess Medical Center · USBoston University · US

Funding

Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
Testing the efficacy of a novel intervention for minimally verbal children with P50DC013027 · NIDCD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SHINN-CUNNINGHAM, BARBARA · 2012 to 2016
$9.4M
Behavioral and Neural Correlates of Melodic Intonation TherapyR01DC008796 · NIDCD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SCHLAUG, GOTTFRIED · 2008 to 2012
$2.0M
Autism Speaks 7504Autism Speaks AS7504NCATS NIH HHS UL1 TR000170NIDCD NIH HHS P50 DC013027NIDCD NIH HHS P50 DC 13027NIDCD NIH HHS R01 DC008796
6 · The paper itself

Abstract

We investigated the relationship between eight theoretically motivated behavioral variables and a spoken-language-related outcome measure, after 25 sessions of treatment for speech production in 38 minimally verbal children with autism. After removing potential predictors that were uncorrelated with the outcome variable, two remained. We used both complete-case and multiple-imputation analyses to address missing predictor data and performed linear regressions to identify significant predictors of change in percent syllables approximately correct after treatment. Baseline phonetic inventory (the number of English phonemes repeated correctly) was the most robust predictor of improvement. In the group of 17 participants with complete data, ADOS score also significantly predicted the outcome. In contrast to some earlier studies, nonverbal IQ, baseline levels of expressive language, and younger age did not significantly predict improvement. The present results are not only consistent with previous studies showing that verbal imitation and autism severity significantly predict spoken language outcomes in preschool-aged minimally verbal children with autism, but also extend these findings to older minimally verbal children with autism. Autism Res 2018, 11: 1356-1365. © 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We wished to understand what baseline factors predicted whether minimally verbal children with autism would improve after treatment for spoken language. The outcome measure was change in percentage (%) syllables approximately correct on a set of 30 two-syllable words or phrases. Fifteen were both practiced in treatment and tested; the remainder were not practiced in treatment, but only tested, to assess how well children were able to generalize their new skills to an untrained set of words. Potential predictors tested were sex, age, expressive language, phonetic inventory (the number of English speech sounds repeated correctly), autism severity, and nonverbal IQ. Phonetic inventory and (for some children) autism severity predicted children's posttreatment improvement. Nonverbal IQ and expressive language ability did not predict improvement, nor did younger age, suggesting that some older children with autism may be candidates for speech therapy.

Indexed as

Autism Spectrum DisorderAutistic DisorderChildChild BehaviorChild, PreschoolFemaleHumansLanguage Development DisordersMaleOutcome Assessment, Health CareSpeechautism spectrum disorderintonationlongitudinal data analysisminimally verbalspoken language

Identifiers

PMID30230700
PMCPMC6203638
OpenAlexW2890102312

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.