Evidence map›Paper›PMID 30230685›Full record

ArticleJournal of biomedical materials research. Part B, Applied biomaterials2019

Antibacterial 3D bone scaffolds for tissue engineering application.

Jitendra Pant, Jaya Sundaram, Marcus J Goudie, Dieu Thao Nguyen, Hitesh Handa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Nitric Oxide: Physiological Functions, Delivery, and Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jitendra PantSchool of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, Georgia.
Jaya SundaramSchool of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, Georgia.
Marcus J GoudieSchool of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, Georgia.
Dieu Thao NguyenSchool of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, Georgia.
Hitesh HandaSchool of Chemical, Materials and Biomedical Engineering, University of Georgia, Athens, Georgia.
University of Georgia · US

Funding

Prevention of Thrombosis by NO Secreting PolymersK25HL111213 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HANDA, HITESH · 2012 to 2016
$739k
NHLBI NIH HHS K25 HL111213NIH HHS K25HL111213
6 · The paper itself

Abstract

Open bone fractures are not only difficult to heal but also are at a high risk of infections. Annual cases of fractures which result from osteoporosis amount to approximately 9 million. Endogenously released nitric oxide (NO) has been shown to play a role in osteogenic differentiation in addition to eradicating infection against a wide variety of pathogens. In the current work, antimicrobial NO releasing 3D bone scaffolds were fabricated using S-nitroso-N-acetyl-penicillamine (SNAP) as the NO donor. During fabrication, nano-hydroxyapatite (nHA) was added to each of the scaffolds in the concentration range of 10-50 wt % in nHA-starch-alginate and nHA-starch-chitosan scaffolds. The mechanical strength of the scaffolds increased proportionally to the concentration of nHA and 50 wt % nHA-starch-alginate possessed the highest load bearing capacity of 203.95 ± 0.3 N. The NO flux of the 50 wt % nHA-starch-alginate scaffolds was found to be 0.50 ± 0.06 × 10

Indexed as

Anti-Bacterial AgentsBone and BonesS-Nitroso-N-AcetylpenicillamineTissue Engineering3T3 CellsAnimalsChitosanMicePseudomonas aeruginosaStaphylococcus aureusStarchTissue ScaffoldsAnti-Bacterial AgentsChitosanS-Nitroso-N-AcetylpenicillamineStarch3D bone scaffoldsalginateantibacterial propertybone injurieschitosaninfectionsnano-hydroxyapatite (nHA)nitric oxide

Identifiers

PMID30230685
PMCPMC9683087
OpenAlexW2891852249

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.