Evidence map›Paper›PMID 30230646›Full record

ArticleNMR in biomedicine2018

Investigation of analysis methods for hyperpolarized 13C-pyruvate metabolic MRI in prostate cancer patients.

Peder E Z Larson, Hsin-Yu Chen, Jeremy W Gordon, Natalie Korn, John Maidens, Murat Arcak, Shuyu Tang, Mark Criekinge, Lucas Carvajal, Daniele Mammoli and 7 more

Open access · greenAbstract read
In one paragraph

Article in NMR in biomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
5.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 107 citations in OpenAlex.

  1. Article
  2. Review
  3. Multimodal Imaging of Hypoxia, Metabolism and pH in Feline Sarcoma Using HyperpolarizedAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Stable electron-irradiated [1-Science advances · 2025
    Article
  9. Article
  10. Consensus recommendations for hyperpolarized [1-Magnetic resonance in medicine · 2025
    Article
  11. Clinical Translation of HyperpolarizedAJNR. American journal of neuroradiology · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Metabolic Imaging of Hyperpolarized [1-International journal of molecular sciences · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025
    Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Peder E Z LarsonDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California.ORCID 0000-0003-4183-3634
Hsin-Yu ChenDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California.ORCID 0000-0002-2765-1685
Jeremy W GordonDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California.
Natalie KornDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California.
John MaidensDepartment of Electrical Engineering and Computer Sciences, University of California - Berkeley, Berkeley, California.
Murat ArcakDepartment of Electrical Engineering and Computer Sciences, University of California - Berkeley, Berkeley, California.
Shuyu TangDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California.
Mark CriekingeDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California.
Lucas CarvajalDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California.
Daniele MammoliDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California.
Robert BokDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California.
Rahul AggarwalDepartment of Medicine, University of California - San Francisco, San Francisco, California.
Marcus FerroneDepartment of Clinical Pharmacy, University of California - San Francisco, San Francisco, California.
James B SlaterDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California.
Sarah J NelsonDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California.
John KurhanewiczDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California.
Daniel B VigneronDepartment of Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, California.
University of California, San Francisco · USUniversity of California, Berkeley · US

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI John Kurhanewicz · 2011 to 2026
$19.9M
Development and Translation of Hyperpolarized C-13 Prostate Cancer MRI MethodsR01EB017449 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KURHANEWICZ, JOHN, VIGNERON, DANIEL B · 2013 to 2017
$5.9M
Translating HP 13C MRI as a Novel Paradigm for Assessing Drug Target InhibitionR01CA183071 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HURD, RALPH EUGENE, MUNSTER, PAMELA N. · 2014 to 2018
$3.3M
Multi-Site Development & Evaluation of a Quantitative 3D Hyperpolarized C-13 MRI Clinical Prostate Cancer ExamR01CA211150 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BANKSON, JAMES A · 2017 to 2021
$3.2M
Hyperpolarized C-13 Diffusion MRI Measures of Cellular Transport and MetabolismR01EB016741 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL · 2014 to 2017
$2.0M
NCI NIH HHS R01 CA183071NCI NIH HHS R01 CA211150NIBIB NIH HHS P41 EB013598NIBIB NIH HHS R01 EB016741NIBIB NIH HHS R01 EB017449NIH HHS P41EB013598NIH HHS R01CA183071NIH HHS R01CA211150NIH HHS R01EB016741NIH HHS R01EB017449
6 · The paper itself

Abstract

MRI using hyperpolarized (HP) carbon-13 pyruvate is being investigated in clinical trials to provide non-invasive measurements of metabolism for cancer and cardiac imaging. In this project, we applied HP [1-

Indexed as

Magnetic Resonance ImagingArea Under CurveCarbon IsotopesComputer SimulationHumansMaleMiddle AgedProstatic NeoplasmsPyruvic AcidCarbon-13Carbon IsotopesPyruvic Acid13C-pyruvatehyperpolarized MRIkinetic modelingmetabolic imagingprostate cancer

Identifiers

PMID30230646
PMCPMC6392436
OpenAlexW2892266580

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.