ArticleMagnetic resonance in medicine2019
White matter intercompartmental water exchange rates determined from detailed modeling of the myelin sheath.
Article in Magnetic resonance in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Axon Diameter Mapping From Myelin Water Diffusion MRI.IEEE transactions on medical imaging · 2026Article
- Field Strength-Dependent White Matter RMagnetic resonance in medicine · 2026Article
- Quantum magnetization exchange through transient hydrogen bond matrix defines magnetic resonance signal relaxation and anisotropy in central nervous system.Scientific reports · 2025Article
- Dependence of brain-tissue RMagnetic resonance in medicine · 2025Article
- Metabolic Energy is Stored in a Homeostatic Trans-Membrane Water Barochemical Gradient.The Journal of membrane biology · 2025Article
- Compartmental anisotropy of filtered exchange imaging (FEXI) in human white matter: What is happening in FEXI?Magnetic resonance in medicine · 2024Article
- Nonaqueous magnetization following adiabatic and selective pulses in brain: T1 and cross-relaxation dynamics.NMR in biomedicine · 2023Article
- Measuring water exchange on a preclinical MRI system using filter exchange and diffusion time dependent kurtosis imaging.Magnetic resonance in medicine · 2023Article
- Dual-encoded magnetization transfer and diffusion imaging and its application to tract-specific microstructure mapping.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Fiber-orientation independent component of RFrontiers in neuroscience · 2023Article
- Evaluating brain damage in multiple sclerosis with simultaneous multi-angular-relaxometry of tissue.Annals of clinical and translational neurology · 2022Article
- Multi-compartment analysis of the complex gradient-echo signal quantifies myelin breakdown in premanifest Huntington's disease.NeuroImage. Clinical · 2021Article
- BNeuroImage · 2020Article
- Quantitative age-dependent differences in human brainstem myelination assessed using high-resolution magnetic resonance mapping.NeuroImage · 2020Article
- Adult brain aging investigated using BMC-mcDESPOT-based myelin water fraction imaging.Neurobiology of aging · 2020Article
- Dipolar induced spin-lattice relaxation in the myelin sheath: A molecular dynamics study.Scientific reports · 2019Article
- Inherent and unpredictable bias in multi-component DESPOT myelin water fraction estimation.NeuroImage · 2019Article
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2 authors.
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Abstract
purposeMagnetization exchange (ME) between hydrogen protons of water and large molecules (semisolids [SS]) in lipid bilayers is an important factor in MRI signal generation and can be exploited to study white matter pathology. Current models used to quantify ME in white matter generally consider water to reside in 1 or 2 distinct compartments, ignoring the complexities of the myelin sheath's multicompartment structure of alternating myelin SS and myelin water (MW) layers. Here, we investigated the effect of this by fitting ME data obtained from human brain at 7 T with a multilayer model of myelin.
methodsA multi-echo acquisition for a T
resultsThe estimated lifetime within a single MW layer was 260 µs, corresponding to a lipid bilayer permeability of 6.7 µm/s. The magnetization lifetime of the aggregate of all MW was estimated at 13 ms, shorter than previously reported values in the range of 40 to 140 ms.
conclusionContrary to expectations and previous reports, ME between protons in myelin SS and water is not limited by the myelin sheath but rather by the exchange between SS and water protons. The analysis of ME contrast should account for the relatively short MW lifetime and affects the interpretation of tissue compartmentalization from MRI contrasts such as T
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