Evidence map›Paper›PMID 30230416›Full record

ArticleAdipocyte2018

Subcutaneous adipose tissue accumulation protects systemic glucose tolerance and muscle metabolism.

A D Booth, A M Magnuson, J Fouts, Y Wei, D Wang, M J Pagliassotti, M T Foster

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Adipocyte, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

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  6. [Association Between Obesity and Dyslipidemia Among Adults in Three Counties (Cities) of Sichuan Province].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

A D Bootha Department of Food Science and Human Nutrition , Colorado State University , Fort Collins , CO , USA.
A M Magnusona Department of Food Science and Human Nutrition , Colorado State University , Fort Collins , CO , USA.ORCID 0000-0001-8418-8001
J Foutsa Department of Food Science and Human Nutrition , Colorado State University , Fort Collins , CO , USA.
Y Weia Department of Food Science and Human Nutrition , Colorado State University , Fort Collins , CO , USA.
D Wanga Department of Food Science and Human Nutrition , Colorado State University , Fort Collins , CO , USA.
M J Pagliassottia Department of Food Science and Human Nutrition , Colorado State University , Fort Collins , CO , USA.
M T Fostera Department of Food Science and Human Nutrition , Colorado State University , Fort Collins , CO , USA.ORCID 0000-0002-3232-6924
Colorado State University · US

Funding

Metabolic Benefits Of Peripheral Fat AccumulationR03DK099425 · NIDDK · COLORADO STATE UNIVERSITY · PI FOSTER, MICHELLE T. · 2014 to 2015
$149k
NIDDK NIH HHS R03 DK099425
6 · The paper itself

Abstract

The protective effects of lower body subcutaneous adiposity are linked to the depot functioning as a "metabolic sink" receiving and sequestering excess lipid. This postulate, however, is based on indirect evidence. Mechanisms that mediate this protection are unknown. Here we directly examined this with progressive subcutaneous adipose tissue removal. Ad libitum chow fed mice underwent sham surgery, unilateral or bilateral removal of inguinal adipose tissue or bilateral removal of both inguinal and dorsal adipose tissue. Subsequently mice were separated into 5 week chow or 5 or 13 week HFD groups (N = 10 per group). Primary outcome measures included adipocyte distribution, muscle and liver triglycerides, glucose tolerance, circulating adipocytokines and muscle insulin sensitivity. Subcutaneous adipose tissue removal caused lipid accumulation in femoral muscle proximal to excision, however, lipid accumulation was not proportionally inverse to adipose tissue quantity excised. Accumulative adipose removal was associated with an incremental reduction in systemic glucose tolerance in 13 week HFD mice. Although insulin-stimulated pAkt/Akt did not progressively decrease among surgery groups following 13 weeks of HFD, there was a suppressed pAkt/Akt response in the non-insulin stimulated (saline-injected) 13 week HFD mice. Hence, increases in lower body subcutaneous adipose removal resulted in incremental decreases in the effectiveness of basal insulin sensitivity of femoral muscle. The current data supports that the subcutaneous depot protects systemic glucose homeostasis while also protecting proximal muscle from metabolic dysregulation and lipid accumulation. Removal of the "metabolic sink" likely leads to glucose intolerance because of decreased storage space for glucose and/or lipids.

Indexed as

Lipid MetabolismAdiposityAnimalsDiet, High-FatGlucoseGlucose IntoleranceInsulinInsulin ResistanceMaleMiceMice, Inbred C57BLMusclesProtective FactorsSubcutaneous FatGlucoseInsulinadipose tissue distributionlipectomymetabolic sinkmusclesubcutaneous adipose tissuetriglyceridevisceral adipose tissue

Identifiers

PMID30230416
PMCPMC6768251
OpenAlexW2891615298

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.